Skip to main content
SpringerLink
Log in

Do vertical shifts in dose-response rate-relationships in operant conditioning procedures indicate “sensitization” to “drug wanting”?

  • Letter to the Editors
  • Published:
Psychopharmacology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1.
Fig. 2.

References

  • Ahmed SH, Koob GF (1998) Transition from moderate to excessive drug intake: change in hedonic set point. Science 282:298–300

    CAS  PubMed  Google Scholar 

  • Deroche V, Le Moal M, Piazza PV (1999) Cocaine self-administration increases the incentive motivational properties of the drug in rats. Eur J Neurosci 11:2731–2736

    CAS  PubMed  Google Scholar 

  • Emmet-Oglesby MW, Peltier RL, Depoortere RY, Pickering CL, Hooper ML, Gong YH, Lane JD (1993) Tolerance to self-administration of cocaine in rats: time course and dose-response determination using a multi-dose method. Drug Alcohol Depend 32:247–256

    Google Scholar 

  • Koob GF, Le Moal M (2001) Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology 24:97–129

    CAS  PubMed  Google Scholar 

  • Negus SS, Mello NK (2003) Effects of chronic d-amphetamine treatment on cocaine- and food-maintained responding under a second-order schedule in rhesus monkeys. Drug Alcohol Depend 70:39–52

    Article  CAS  PubMed  Google Scholar 

  • Piazza PV, Deroche-Gamonent V, Rouge-Pont F, Le Moal M (2000) Vertical shifts in self-administration dose-response functions predict a drug-vulnerable phenotype predisposed to addiction. J Neurosci 20:4226–4232

    CAS  PubMed  Google Scholar 

  • Robinson TE, Berridge KC (1993) The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Brain Res Rev 18:247–291

    CAS  PubMed  Google Scholar 

  • Robinson TE, Berridge KC (2001) Incentive-sensitization and addiction. Addiction 96:103–114

    CAS  PubMed  Google Scholar 

  • Wakonigg G, Sturm K, Saria A, Zernig G (2003) Opioids, cocaine, and food change runtime distribution in a rat runway procedure. Psychopharmacology 169:52–59

    Google Scholar 

  • Winger G, Woods JH (2001) The effects of chronic morphine on behavior reinforced by several opioids or by cocaine in rhesus monkeys. Drug Alcohol Depend 62:181–189

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgement

Supported by the Austrian Science Fund (P16394-B05).

Author information

Authors and Affiliations

  1. Division of Neurochemistry, Department of Psychiatry, University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria

    Gerald Zernig, Gudrun Wakonigg & Alois Saria

  2. Primariat B, Psychiatric Hospital Hall in Tirol, Austria

    Ekkehard Madlung & Christian Haring

Authors
  1. Gerald Zernig
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gudrun Wakonigg
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ekkehard Madlung
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Christian Haring
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Alois Saria
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gerald Zernig.

Additional information

Replies to this letter are available at http://dx.doi.org/10.1007/s00213-003-1602-z, http://dx.doi.org/10.1007/s00213-003-1603-y, http://dx.doi.org/10.1007/s00213-003-1604-x, http://dx.doi.org/10.1007/s00213-003-1605-9 and http://dx.doi.org/10.1007/s00213-003-1606-8

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zernig, G., Wakonigg, G., Madlung, E. et al. Do vertical shifts in dose-response rate-relationships in operant conditioning procedures indicate “sensitization” to “drug wanting”?. Psychopharmacology 171, 349–351 (2004). https://doi.org/10.1007/s00213-003-1601-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00213-003-1601-0

Keywords

Search

Navigation