Abstract
The number of colony-forming cells (CFC) in the peripheral blood (PB) of 43 volunteers was examined using a semisolid clonogenic culture assay. In all, 22 male (age 21–39 years) and 21 female individuals (age 21–39 years) were tested, ten of each group twice to examine the intraindividual variability of colony-forming cells in PB. A statistically significant sex difference in the number of CFC, erythroblastic colonies (BFU-E), and granulocyte/macrophage colonies (CFU-GM) in PB was detected in favor of male individuals. No significant difference between female and male PB was found for the number of CFU-GEMM. The intraindividual variability of CFC and BFU-E was significantly higher in female donors. These results support previous reports by others on a potential influence of sex steroids on hematopoiesis.
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Received: 8 November 1996 / Accepted: 4 April 1997
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Hörner, S., Pasternak, G. & Hehlmann, R. A statistically significant sex difference in the number of colony-forming cells from human peripheral blood. Ann Hematol 74, 259–263 (1997). https://doi.org/10.1007/s002770050296
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DOI: https://doi.org/10.1007/s002770050296