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3-Iodothyronamine: a novel hormone controlling the balance between glucose and lipid utilisation

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Abstract

3-Iodothyronamine is considered as a derivate of thyroid hormone as a result of enzymatic deiodination and decarboxylation. The physiological role of thyronamine (T1AM) is not known. The aim of this study was to analyze the metabolic response to T1AM in the Djungarian hamster Phodopus sungorus. We measured the influence of T1AM (50 mg/kg) on metabolic rate (VO2), body temperature (T b) and respiratory quotient (RQ) in this species and in BL/6 mice. T1AM treated hamsters as well as the mice showed a rapid decrease in VO2 and T b, accompanied by a reduction of RQ from normal values of about ∼0.9 to ∼0.70 for several hours. This indicates that carbohydrate utilisation is blocked by the injection of T1AM and that metabolic pathways are rerouted from carbohydrate to lipid utilisation in response to T1AM. This assumption was further supported by the observation that the treatment of T1AM caused ketonuria and a significant loss of body fat. Our results indicate that T1AM has the potential to control the balance between glucose and lipid utilisation in vivo.

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Abbreviations

2-DG:

2-Deoxy-d-glucose

BM:

Body mass

DEXA:

Dual energy X-ray absorption

DMSO:

Dimethyl sulfoxide

FM:

Fat mass

LM:

Lean mass

LP:

Long photoperiod

MA:

Mercaptoacetate

MP:

Methyl palmoxirate

RQ:

Respiratory quotient

SP:

Short photoperiod

T1AM:

3-Iodothyronamine

T a :

Ambient temperature

T b :

Body temperature

TH:

Thyroid hormone

VO2 :

Metabolic rate (volume oxygen consumed)

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Authors and Affiliations

  1. Department of Biology, Philipps-University Marburg, Karl von Frisch Str.8, 35032, Marburg, Germany

    L. J. Braulke, M. Klingenspor & G. Heldmaier

  2. Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, OR, USA

    A. DeBarber, D. K. Grandy & T. S. Scanlan

  3. Department of Pharmaceutical Chemistry, University of California-San Francisco, San Francisco, CA, USA

    S. C. Tobias & T. S. Scanlan

Authors
  1. L. J. Braulke
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  2. M. Klingenspor
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  3. A. DeBarber
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  4. S. C. Tobias
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  5. D. K. Grandy
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  6. T. S. Scanlan
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  7. G. Heldmaier
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Corresponding author

Correspondence to L. J. Braulke.

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Communicated by H.V. Carey.

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Braulke, L.J., Klingenspor, M., DeBarber, A. et al. 3-Iodothyronamine: a novel hormone controlling the balance between glucose and lipid utilisation. J Comp Physiol B 178, 167–177 (2008). https://doi.org/10.1007/s00360-007-0208-x

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  • DOI: https://doi.org/10.1007/s00360-007-0208-x

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