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Estrogen and hypertension

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Abstract

Menopause is accompanied by a dramatic rise in the prevalence of hypertension in women, suggesting a protective role of endogenous estradiol on blood pressure (BP). Both animal experimental and human clinical investigations suggest that estrogen engages several mechanisms that protect against hypertension, such as activation of the vasodilator pathway mediated by nitric oxide and prostacyclin and inhibition of the vasoconstrictor pathway mediated by the sympathetic nervous system and angiotensin. However, emerging evidence from recent clinical trials indicates a small increase, rather than decrease, in systolic BP with oral estrogen administration in postmenopausal women, without any detectable effect on diastolic BP. Mechanisms underlying this selective rise in systolic BP in postmenopausal women and oral contraceptive-induced hypertension in premenopausal women remain unknown, but the rise may be related to supraphysiologic concentration of estrogen in the liver. To date, transdermal delivery of estrogen, which avoids the first-pass hepatic metabolism of estradiol, appears to have a small BP-lowering effect in postmenopausal women and may be a safer alternative in hypertensive women.

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References and Recommended Reading

  1. Thom T, Haase N, Rosamond W, et al.: Heart disease and stroke statistics—2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2006, 113:e85-e151.

    Article  PubMed  Google Scholar 

  2. American Cancer Society. Cancer Facts & Figures 2003, 2003. http://www.cancer.org/docroot/STT/STT_0.asp. Accessed June 30, 2006.

  3. Hajjar I, Kotchen TA: Trends in prevalence, awareness, treatment, and control of hypertension in the United States, 1988–2000. JAMA 2003, 290:199–206.

    Article  PubMed  Google Scholar 

  4. Owens J, Stoney C, Matthews K: Menopausal status influences ambulatory blood pressure levels and blood pressure levels and blood pressure changes during mental stress. Circulation 1993, 88:2794–2802.

    PubMed  CAS  Google Scholar 

  5. Mercuro G, Zoncu S, Saiu F, et al.: Menopause induced by oophorectomy reveals a role of ovarian estrogen on the maintenance of pressure homeostasis. Maturitas 2004, 47:131–138.

    Article  PubMed  CAS  Google Scholar 

  6. Schillaci G, Verdecchia P, Borgioni C, et al.: Early cardiac changes after menopause. Hypertension 1998, 32:764–769.

    PubMed  CAS  Google Scholar 

  7. Gravholt C, Naeraa RW, Nyholm B, et al.: Glucose metabolism, lipid metabolism, and cardiovascular risk factors in adult Turner’s syndrome. The impact of sex hormone replacement. Diabetes Care 1998, 21:1062–1070.

    Article  PubMed  CAS  Google Scholar 

  8. Zhu Y, Bian Z, Lu P, et al.: Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta. Science 2002, 295:505–508.

    Article  PubMed  CAS  Google Scholar 

  9. Ogawa S, Emi M, Shiraki M, et al.: Association of estrogen receptor beta (ESR2) gene polymorphism with blood pressure. J Hum Genet 2000, 45:327–330.

    Article  PubMed  CAS  Google Scholar 

  10. Peter I, Shearman AM, Zucker DR, et al.: Variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in the Framingham Heart Study. J Hypertens 2005, 23:2193–2200.

    Article  PubMed  CAS  Google Scholar 

  11. Kublickiene K, Svedas E, Landgren BM, et al.: Small artery endothelial dysfunction in postmenopausal women: in vitro function, morphology, and modification by estrogen and selective estrogen receptor modulators. J Clin Endocrinol Metab 2005, 90:6113–6122.

    Article  PubMed  CAS  Google Scholar 

  12. Ouyang P, Michos ED, Karas RH: Hormone replacement therapy and the cardiovascular system: lessons learned and unanswered questions. J Am Coll Cardiol 2006, 47:1741–1753. This comprehensive review provides an update of experimental and clinical data regarding the effects of estrogen on the cardiovascular system.

    Article  PubMed  CAS  Google Scholar 

  13. Koh KK, Ahn JY, Jin DK, et al.: Effects of continuous combined hormone replacement therapy on inflammation in hypertensive and/or overweight postmenopausal women. Arteriolscler Thromb Vasc Biol 2002, 22:1459–1464.

    Article  CAS  Google Scholar 

  14. Girdler SS, Hinderliter AL, Wells EC, et al.: Transdermal versus oral estrogen therapy in postmenopausal smokers: hemodynamic and endothelial effects. Obstet Gynecol 2004, 103:169–180.

    PubMed  CAS  Google Scholar 

  15. Vehkavaara S, Hakala-Ala-Pietila T, Virkamaki A, et al.: Differential effects of oral and transdermal estrogen replacement therapy on endothelial function in postmenopausal women. Circulation 2000, 102:2687–2693.

    PubMed  CAS  Google Scholar 

  16. Honisett SY, Stojanovska L, Sudhir K, et al.: Hormone therapy impairs endothelial function in postmenopausal women with type 2 diabetes mellitus treated with rosiglitazone. J Clin Endocrinol Metab 2004, 89:4615–4619.

    Article  PubMed  CAS  Google Scholar 

  17. Staessen JA, van der Heijden-Spek JJ, Safar ME, et al.: Menopause and the characteristics of the large arteries in a population study. J Hum Hypertens 2001, 15:511–518.

    Article  PubMed  CAS  Google Scholar 

  18. Staessen J, Ginocchino G, Thijs L, Fagard R: Conventional and ambulatory blood pressure and menopause in a prospective population study. J Hum Hypertens 1997, 11:507–514.

    Article  PubMed  CAS  Google Scholar 

  19. da Costa LS, de Oliveira MA, Rubim VS, et al.: Effects of hormone replacement therapy or raloxifene on ambulatory blood pressure and arterial stiffness in treated hypertensive postmenopausal women. Am J Cardiol 2004, 94:1453–1456.

    Article  PubMed  CAS  Google Scholar 

  20. Bui MN, Arai AE, Hathaway L, et al.: Effect of hormone replacement therapy on carotid arterial compliance in healthy postmenopausal women. Am J Cardiol 2002, 90:82–85.

    Article  PubMed  CAS  Google Scholar 

  21. Sumino H, Ichikawa S, Kasama S, et al.: Different effects of oral conjugated estrogen and transdermal estradiol on arterial stiffness and vascular inflammatory markers in postmenopausal women. Atherosclerosis 2006, Feb 7 [Epub ahead of print].

  22. Schulman IH, Aranda P, Raij L, et al.: Surgical menopause increases salt sensitivity of blood pressure. Hypertension 2006, Apr 17 [Epub ahead of print]. First prospective study of effects of oophorectomy on salt sensitivity in humans.

  23. Harrison-Bernard LM, Schulman IH, Raij L: Postovariectomy hypertension is linked to increased renal AT1 receptor and salt sensitivity. Hypertension 2003, 42:1157–1163.

    Article  PubMed  CAS  Google Scholar 

  24. Hinojosa-Laborde C, Lange DL, Haywood JR: Role of female sex hormones in the development and reversal of Dahl hypertension. Hypertension 2000, 35(Part 2):484–489.

    PubMed  CAS  Google Scholar 

  25. Hinojosa-Laborde C, Craig T, Zheng W, et al.: Ovariectomy augments hypertension in aging female Dahl salt-sensitive rats. Hypertension 2004, 44:405–409.

    Article  PubMed  CAS  Google Scholar 

  26. Scuteri A, Lakatta EG, Anderson DE, Fleg JL: Transdermal 17 beta-oestradiol reduces salt sensitivity of blood pressure in postmenopausal women. J Hypertens 2003, 21:2419–2420.

    Article  PubMed  CAS  Google Scholar 

  27. Schunkert H, Danser AH, Hense HW, et al.:Effects of estrogen replacement therapy on the renin-angiotensin system in postmenopausal women. Circulation 1997, 95:39–45.

    PubMed  CAS  Google Scholar 

  28. Seely E, Broshinan B, Jeunemaitre X, et al.: Effects of conjugated estrogen and droloxifene on the renin-angiotensin system, blood pressure, and renal blood flow in postmenopausal women. Clin Endocrinol 2004, 60:315–321.

    Article  CAS  Google Scholar 

  29. Harvey PJ, Morris BL, Miller JA, Floras JS: Estradiol induces discordant angiotensin and blood pressure responses to orthostasis in healthy postmenopausal women. Hypertension 2005, 45:399–405.

    Article  PubMed  CAS  Google Scholar 

  30. Brown NJ, Abbas A, Byrne D, et al.: Comparative effects of estrogen and angiotensin-converting enzyme inhibition on plasminogen activator inhibitor-1 in healthy postmenopausal women. Circulation 2002, 105:304–309.

    Article  PubMed  CAS  Google Scholar 

  31. Seely E, Walsh B, Gerhard M, Williams G: Estradiol with or without progesterone and ambulatory blood pressure in postmenopausal women. Hypertension 1999, 33:1190 -1194.

    PubMed  CAS  Google Scholar 

  32. Nickenig G, Strehlow K, Wassmann S, et al.: Differential effects of estrogen and progesterone on AT(1) receptor gene expression in vascular smooth muscle cells. Circulation 2000, 102:1828–1833.

    PubMed  CAS  Google Scholar 

  33. Jhund PS, Dawson N, Davie AP, et al.: 17ss oestradiol does not attenuate the response to angiotensin I and II during long term therapy in postmenopausal women. Cardiovasc Drugs Ther 2004, 18:31–36.

    Article  PubMed  CAS  Google Scholar 

  34. Matsukawa T, Sugiyama Y, Watanabe T, et al.: Gender difference in age-related changes in muscle sympathetic nerve activity in healthy subjects. Am J Physiol 1998, 275:R1600-R1604.

    PubMed  CAS  Google Scholar 

  35. Ettinger SM, Silber DH, Gray KS, et al.: Effects of the ovarian cycle on sympathetic neural outflow during static exercise. J Appl Physiol 1998, 85:2075–2081.

    PubMed  CAS  Google Scholar 

  36. Simonian SX, Delaleu B, Caraty A, Herbison AE: Estrogen receptor expression in brainstem noradrenergic neurons of the sheep. Neuroendocrinology 1998, 67:392–402.

    Article  PubMed  CAS  Google Scholar 

  37. Del Rio G, Velardo A, Menozzi R, et al.: Acute estradiol and progesterone administration reduced cardiovascular and catecholamine responses to mental stress in menopausal women. Neuroendocrinology 1998, 67:296–274.

    Google Scholar 

  38. Vongpatanasin W, Tuncel M, Mansour Y, et al.: Estrogen replacement therapy decreases sympathetic vasoconstrictor activity in postmenopausal women. Circulation 2001, 103:2903–2908.

    PubMed  CAS  Google Scholar 

  39. Weitz G, Elam M, Born J, et al.: Postmenopausal estrogen administration suppresses muscle sympathetic nerve activity. J Clin Endocrinol Metab 2001, 86:344–348.

    Article  PubMed  CAS  Google Scholar 

  40. Hunt BE, Taylor JA, Hamner JW, et al.: Estrogen replacement therapy improves baroreflex regulation of vascular sympathetic outflow in postmenopausal women. Circulation 2001, 103:2909–2914.

    PubMed  CAS  Google Scholar 

  41. O’Sullivan AJ, Crampton LJ, Freund J, Ho KKY: The route of estrogen replacement confers divergent effects on substrate oxidation and body composition in postmenopausal women. J Clin Invest 1998, 102:1035–1040.

    PubMed  CAS  Google Scholar 

  42. Duanmu Z, Lapanowski K, Dunbar JC: Insulin-like growth factor-I decreases sympathetic nerve activity: The effect is modulated by glycemic status. Proc Soc Exp Biol Med 1997, 216:93–97.

    PubMed  CAS  Google Scholar 

  43. Sverrisdottir YB, Elam M, Herlitz H, et al.: Intense sympathetic nerve activity in adults with hypopituitarism and untreated growth hormone deficiency. J Clin Endocrinol Metab 1998, 83:1881–1885.

    Article  PubMed  CAS  Google Scholar 

  44. Scherrer U, Randin D, Tappy L, et al.: Body fat and sympathetic nerve activity in healthy subjects. Circulation 1994, 89:240–263.

    Google Scholar 

  45. Oishi A, Ohmichi M, Takahashi K, et al.: Medroxyprogesterone acetate attenuates estrogen-induced nitric oxide production in human umbilical vein endothelial cells. Biochem Biophys Res Commun 2004, 324:193–198.

    Article  PubMed  CAS  Google Scholar 

  46. Mikkola T, Viinikka L, Ylikorkala O: Administration of transdermal estrogen without progestin increases the capacity of plasma and serum to stimulate prostacyclin production in human vascular endothelial cells. Fertil Steril 2000, 73:72–74.

    Article  PubMed  CAS  Google Scholar 

  47. Lima SM, Aldrighi JM, Consolim-Colombo FM, et al.: Acute administration of 17beta-estradiol improves endotheliumdependent vasodilation in postmenopausal women. Maturitas 2005, 50:266–274.

    Article  PubMed  CAS  Google Scholar 

  48. Polvani G, Marino MR, Roberto M, et al.: Acute effects of 17beta-estradiol on left internal mammary graft after coronary artery bypass grafting. Ann Thorac Surg 2002, 74:695–699.

    Article  PubMed  Google Scholar 

  49. Kelemen M, Vaidya D, Waters DD, et al.: Hormone therapy and antioxidant vitamins do not improve endothelial vasodilator function in postmenopausal women with established coronary artery disease: a substudy of the Women’s Angiographic Vitamin and Estrogen (WAVE) trial. Atherosclerosis 2005, 179:193–200.

    Article  PubMed  CAS  Google Scholar 

  50. Duvernoy C, Martin J, Briesmiester K, et al.: Myocardial blood flow and flow reserve in response to hormone therapy in postmenopausal women with risk factors for coronary disease. J Clin Endocrinol Metab 2004, 89:2783–2788.

    Article  PubMed  CAS  Google Scholar 

  51. Oelkers W: Effects of estrogens and progestogens on the renin-aldosterone system and blood pressure. Steroids 1996, 61:166–171.

    Article  PubMed  CAS  Google Scholar 

  52. White WB, Pitt B, Preston RA, Hanes V: Antihypertensive effects of drospirenone with 17beta-estradiol, a novel hormone treatment in postmenopausal women with stage 1 hypertension. Circulation 2005, 112:1979–1984.

    Article  PubMed  CAS  Google Scholar 

  53. Oelkers W, Schoneshofer M, Blumel A: Effects of progesterone and four synthetic progestagens on sodium balance and the renin-aldosterone system in man. J Clin Endocrinol Metab 1974, 39:882–890.

    Article  PubMed  CAS  Google Scholar 

  54. The Writing Group of the PEPI Trial: Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. JAMA 1995, 273:199–208.

    Article  Google Scholar 

  55. Writing Group for the Women’s Health Initiative Investigators: Risks and benefits of estrogen plus progestin in healthy postmenopausal women principal results from the Women’s Health Initiative Randomized Controlled Trial. JAMA 2002, 288:321–333. The largest randomized primary prevention trial of oral conjugated estrogens plus progestins in postmenopausal women with intact uteri.

    Article  Google Scholar 

  56. Anderson GL, Limacher M, Assaf AR, et al.: Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women’s Health Initiative randomized controlled trial. JAMA 2004, 291:1701–1712. The largest randomized primary prevention trial of oral conjugated estrogens alone in postmenopausal women with hysterectomy.

    Article  PubMed  CAS  Google Scholar 

  57. Nair GV, Chaput LA, Vittinghoff E, Herrington DM: Pulse pressure and cardiovascular events in postmenopausal women with coronary heart disease. Chest 2005, 127:1498–1506. Randomized secondary prevention trial of oral conjugated estrogens plus progestins in postmenopausal women with coronary artery disease.

    Article  PubMed  Google Scholar 

  58. Angerer P, Störk S, Kothny W, et al.: Effect of oral postmenopausal hormone replacement on progression of atherosclerosis: a randomized, controlled trial. Arterioscler Thromb Vasc Biol 2001, 21:262–268.

    PubMed  CAS  Google Scholar 

  59. Nair GV, Waters D, Rogers W, et al.: Pulse pressure and coronary atherosclerosis progression in postmenopausal women. Hypertension 2005, 45:53–57.

    PubMed  CAS  Google Scholar 

  60. Staessen JA, Wang JG, Thijs L: Cardiovascular prevention and blood pressure reduction: a quantitative overview updated until 1 March 2003. J Hypertens 2003, 21:1055–1076.

    Article  PubMed  CAS  Google Scholar 

  61. Sesso HD, Buring JE, Rifai N, et al.: C-reactive protein and the risk of developing hypertension. JAMA 2003, 290:2945–2951.

    Article  PubMed  CAS  Google Scholar 

  62. Niskanen L, Laaksonen DE, Nyyssonen K, et al.: Inflammation, abdominal obesity, and smoking as predictors of hypertension. Hypertension 2004, 44:859–865.

    Article  PubMed  CAS  Google Scholar 

  63. Hunt KJ, Lukanova A, Rinaldi S, et al.: A potential inverse association between insulin-like growth factor I and hypertension in a cross-sectional study. Ann Epidemiol 2006, Jan 20 [Epub ahead of print].

  64. Cagnacci A, Rovati L, Zanni A, et al.: Physiological doses of estradiol decrease noctural blood pressure in normotensive postmenopausal women. Am J Physiol 1999, 276:H1355-H1360.

    PubMed  CAS  Google Scholar 

  65. Mercuro G, Zoncu S, Pilia I, et al.: Effects of acute administration of transdermal estrogen on postmenopausal women with systemic hypertension. Am J Cardiol 1997, 80:652–655.

    Article  PubMed  CAS  Google Scholar 

  66. Mercuro G, Zoncu S, Piano D, et al.: Estradiol-17B reduces blood pressure and restores the normal amplitude of the circadian blood pressure rhythm in postmenopausal hypertension. Am J Hypertens 1998, 11:909–913.

    Article  PubMed  CAS  Google Scholar 

  67. Pripp U, Hall G, Csemiczky G, et al.: A randomized trial on effects of hormone therapy on ambulatory blood pressure and lipoprotein levels in women with coronary artery disease. J Hypertens 1999, 17:1379–1386.

    Article  PubMed  CAS  Google Scholar 

  68. Affinito P, Palomba S, Bonifacio M, et al.: Effects of hormonal replacement therapy in postmenopausal hypertensive patients. Maturitas 2001, 40:75–83.

    Article  PubMed  CAS  Google Scholar 

  69. Zacharieva S, Atanassova I, Kirilov G, et al.: Effect of transdermal estrogen therapy on some vasoactive humoral factors and 24-h ambulatory blood pressure in normotensive postmenopausal women. Climacteric 2002, 5:293–299.

    PubMed  CAS  Google Scholar 

  70. Modena MG, Muia N Jr, Aveta P, et al.: Effects of transdermal 17beta-estradiol on left ventricular anatomy and performance in hypertensive women. Hypertension 1999, 34:1041–1046.

    PubMed  CAS  Google Scholar 

  71. Reckelhoff JF: Sex steroids, cardiovascular diseases, and hypertension. Hypertension 2005, 45:170–174.

    Article  PubMed  CAS  Google Scholar 

  72. Christ M, Seyffart K, Hanns-Christian T, Wehling M:.Hormone replacement in postmenopausal women: impact of progestogens on autonomic tone and blood pressure regulation. Menopause 2002, 9:127–136.

    Article  PubMed  Google Scholar 

  73. Sorensen MB, Rasmussen V, Jensen G, Ottesen B: Temporal changes in clinic and ambulatory blood pressure during cyclic post-menopausal hormone replacement therapy. J Hypertens 2000, 18:1387–1391.

    Article  PubMed  CAS  Google Scholar 

  74. Harvey PJ, Molloy D, Upton J, Wing LM: Dose response effect of cyclical medroxyprogesterone on blood pressure in postmenopausal women. J Hum Hypertens 2001, 15:313–321.

    Article  PubMed  CAS  Google Scholar 

  75. Stojanovic ND, Kwong P, Byrne DJ, et al.: The effects of transdermal estradiol alone or with cyclical dydrogesterone on markers of cardiovascular disease risk in postmenopausal women with type 2 diabetes: a pilot study. Angiology 2003, 54:391–399.

    Article  PubMed  CAS  Google Scholar 

  76. Preston RA, White WB, Pitt B, et al.: Effects of drospirenone/ 17-beta estradiol on blood pressure and potassium balance in hypertensive postmenopausal women. Am J Hypertens 2005, 18:797–804.

    Article  PubMed  CAS  Google Scholar 

  77. Woods JW: Oral contraceptives and hypertension. Hypertension 1988, 11:II11-II15.

    PubMed  CAS  Google Scholar 

  78. Hussain SF: Progestogen-only pills and high blood pressure: is there an association. A literature review. Contraception 2004, 69:89–97.

    Article  PubMed  CAS  Google Scholar 

  79. Chasan-Taber L, Willett WC, Manson JE, et al.: Prospective study of oral contraceptives and hypertension among women in the United States. Circulation 1996, 94:483–489.

    PubMed  CAS  Google Scholar 

  80. Cardoso F, Polonia J, Santos A, et al.: Low-dose oral contraceptives and 24-hour ambulatory blood pressure. Int J Gynaecol Obstet 1997, 59:237–243.

    Article  PubMed  CAS  Google Scholar 

  81. Straznicky NE, Barrington VE, Branley P, Louis WJ: A study of the interactive effects of oral contraceptive use and dietary fat intake on blood pressure, cardiovascular reactivity and glucose tolerance in normotensive women. J Hypertens 1998, 16:357–368.

    Article  PubMed  CAS  Google Scholar 

  82. Heintz B, Schmauder C, Witte K, et al.: Blood pressure rhythm and endocrine functions in normotensive women on oral contraceptives. J Hypertens 1997, 14:333–339.

    Article  Google Scholar 

  83. Williamson PM, Buddle ML, Brown MA, Whitworth JA: Ambulatory blood pressure monitoring (ABPM) in the normal menstrual cycle and in women using oral contraceptives. Comparison with conventional blood pressure measurement. Am J Hypertens 1996, 9:953–958.

    Article  PubMed  CAS  Google Scholar 

  84. Narkiewicz K, Graniero GR, D’Este D, et al.: Ambulatory blood pressure in mild hypertensive women taking oral contraceptives. A case-control study. Am J Hypertens 1995, 8:249–253.

    Article  PubMed  CAS  Google Scholar 

  85. Lubianca JN, Faccin CS, Fuchs FD: Oral contraceptives: a risk factor for uncontrolled blood pressure among hypertensive women. Contraception 2003, 67:19–24.

    Article  PubMed  CAS  Google Scholar 

  86. Kang AK, Duncan JA, Cattran DC, et al.: Effect of oral contraceptives on the renin angiotensin system and renal function. Am J Physiol Regul Integr Comp Physiol 2001, 280:R807-R813.

    PubMed  CAS  Google Scholar 

  87. Ahmed SB, Kang AK, Burns KD, et al.: Effects of oral contraceptive use on the renal and systemic vascular response to angiotensin II infusion. J Am Soc Nephrol 2004, 15:780–786.

    Article  PubMed  CAS  Google Scholar 

  88. Ribstein J, Halimi JM, du Cailar G, Mimran A: Renal characteristics and effect of angiotensin suppression in oral contraceptive users. Hypertension 1999, 33:90–95.

    PubMed  CAS  Google Scholar 

  89. Pechere-Bertschi A, Maillard M, Stalder H, et al.: Renal hemodynamic and tubular responses to salt in women using oral contraceptives. Kidney Int 2003, 64:1374–1380.

    Article  PubMed  Google Scholar 

  90. Monster TB, Janssen WM, de Jong PE, de Jong-van den Berg LT: Oral contraceptive use and hormone replacement therapy are associated with microalbuminuria. Arch Intern Med 2001, 161:2000–2005.

    Article  PubMed  CAS  Google Scholar 

  91. Lubianca JN, Moreira LB, Gus M, Fuchs FD: Stopping oral contraceptives: an effective blood pressure-lowering intervention in women with hypertension. J Hum Hypertens 2005, 19:451–455.

    Article  PubMed  CAS  Google Scholar 

  92. Vongpatanasin W, Tuncel M, Wang Z, et al.: Differential effects of oral vs. transdermal estrogen replacement therapy on C-reactive protein in postmenopausal women. J Am Coll Cardiol 2003, 41:1358–1363.

    Article  PubMed  CAS  Google Scholar 

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Ashraf, M.S., Vongpatanasin, W. Estrogen and hypertension. Current Science Inc 8, 368–376 (2006). https://doi.org/10.1007/s11906-006-0080-1

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