Clinical studyEffect of schedule of administration on the therapeutic efficacy of penicillin: Importance of the aggregate time penicillin remains at effectively bactericidal levels
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2016, Clinical TherapeuticsCitation Excerpt :β-lactams serve as the archetypal class of time-dependent antibiotics, whereby substantially increasing drug concentrations have minimal effects on the overall rate and extent of bacterial killing. Instead, maintaining a free drug concentration above the MIC of the organism for a portion of the dosing interval has been shown to best predict microbiologic efficacy.142–145 The magnitude of this PD index varies according to β-lactam subclass, with typical fT>MIC values of ≥60% to 70% for cephalosporins, ≥50% for penicillins, and ≥40% for carbapenems providing maximal bactericidal effect.132,133
Pharmacokinetics and pharmacodynamics of antibiotics in the critically ill patient: Part Two
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From the Section on Experimental Therapeutics, Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, Md.