ReviewAutacoids as modulators of the inflammatory and immune response☆
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Cited by (65)
Pro-resolving lipid mediators: Agents of anti-ageing?
2018, Seminars in ImmunologyCitation Excerpt :These tissue manifestations of inflammation are directed by autacoids creating chemical gradients that dictate trafficking of leucocytes to injured tissue. These chemical mediators include peptides, proteins and lipid-derived mediators [2,3]. Initial observations that some lipid-derived mediators acted to inhibit polymorphonuclear cell (PMN) trafficking led to the proposal that they acted as “stop” signals, or brakes, in inflammation.
Stinging nettles leaf (Urtica dioica L.): Extraordinary vegetable medicine
2013, Journal of Herbal MedicineCitation Excerpt :Besides being a mediator of immediate hypersensitivity allergic reactions, histamine acts as an autacoid (“self medication”) to modulate the immune response. It activates adenylate cyclase via H2-receptors of leukocytes, thereby stimulating the conversion of ATP to cAMP and preventing antigen-induced mediator release from sensitized basophils and mast cells, such as histamine release from ragweed-sensitized cells (Bourne et al., 1974; Melmon et al., 1981). The ability of stinging nettle preparations to inhibit platelet aggregation has been reported in various in vitro models.
Periodic fevers with aphthous stomatitis, pharyngitis, and adenitis (PFAPA)
2012, Autoimmunity ReviewsCitation Excerpt :Cimetidine, a histamine type 2 receptor blocker, was also used, in the past, for the treatment of PFAPA. Cimetidine was shown to have immunomodulating properties such as suppression of CD8 + T-cells, increase INF-gamma production and chemotaxis of neutrophils, increase lysosomal enzyme release and production of migratory inhibitory factors [28,29]. One third of a cohort of children treated with a prophylactic dose of cimetidine of 150 mg twice daily for 6–12 months responded to treatment [7].
Use of the A <inf>2A</inf> adenosine receptor as a physiological immunosuppressor and to engineer inflammation in vivo
2003, Biochemical PharmacologyCitation Excerpt :However, this notion has not been widely accepted by investigators outside this field since adenosine receptors are not the only candidates for this role. Activation of some other Gs protein-coupled cAMP-elevating receptors (including histamine, dopamine, prostaglandin, and β2 adrenergic receptors) can also inhibit inflammatory processes in vivo, which led to their consideration as potential physiological OFF signals [79,81,100,101]. Activation of both A2A and A2B receptors is capable of increasing cAMP levels in immune cells, and both receptors had to be considered as potentially immunosuppressive in vivo.
Ocular mast cells and mediators
1997, Immunology and Allergy Clinics of North AmericaRegulation of IgE and cytokine production by cAMP: Implications for extrinsic asthma
1996, Clinical Immunology and Immunopathology
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This work was supported in part by HL 26340-01.
- 1
From the Department of Medicine, Stanford University School of Medicine, Stanford, California.
- 2
From the Department of Medicine, Tufts University School of Medicine, Boston, Mass.