Original articleInfluence of allopurinol on cardiac complications in open heart operations
References (21)
- et al.
Do calcium-dependent ionic currents mediate ischemic ventricular fibrillation?
Am J Cardiol
(1982) - et al.
Effects of some free radical scavengers on reperfusion induced arrhythmias in the isolated rat heart
J Mol Cell Cardiol
(1985) - et al.
Response of the ischemic myocardium to allopurinol
Am Heart J
(1971) - et al.
The effect of allopurinol on the degree of early myocardial ischemia
Am Heart J
(1980) - et al.
The oxygen free radical system: potential mediator of myocardial injury
J Am Coll Cardiol
(1985) - et al.
Molecular oxygen: friend and foe. The role of the oxygen free radical system in the calcium paradox, the oxygen paradox and ischemia reperfusion injury
J Mol Cell Cardiol
(1984) - et al.
Prevention of free radical-induced myocardial reperfusion injury with allopurinol
J Thorac Cardiovasc Surg
(1985) Oxygen-derived free radicals and postischemic myocardial dysfunction (“stunned myocardium”)
J Am Coll Cardiol
(1988)Myocardial catecholamine release in acute myocardial ischemia; relationship to cardiac arrhythmias
- et al.
Potential electrophysiologic mechanisms responsible for dysrhythmias associated with reperfusion of ischemic myocardium
Circulation
(1983)
Cited by (59)
Allopurinol attenuates oxidative injury in rat hearts suffered ischemia/reperfusion via suppressing the xanthine oxidase/vascular peroxidase 1 pathway
2021, European Journal of PharmacologyCitation Excerpt :Actually, several small-scale clinical trials for patients with acute myocardial infarction, who were undergoing coronary bypass surgery or angioplasty, have been performed to evaluate the effects of allopurinol on myocardial I/R injury. Most clinical studies reported that allopurinol showed cardioprotective effects, including improvement of cardiac performance (scored by cardiac index and the need for inotropic or mechanical support), decrease of the incidence of cardiac complications (such as arrhythmias, heart failure, and myocardial infarction) and inhibition of oxidative stress (Coghlan et al., 1994; Guan et al., 2003; Johnson et al., 1991; Rashid and William-Olsson, 1991; Castelli et al., 1995). However, another clinical study showed that allopurinol failed to improve cardiac function after cardiopulmonary bypass surgery (Coetzee et al., 1996).
Drug repurposing in cardiovascular diseases: Opportunity or hopeless dream?
2020, Biochemical PharmacologyCitation Excerpt :In a RCT enrolling 169 patients, pre-treatment of allopurinol (400–800 mg/day for 2 days) reduced in-hospital mortality (4 vs 18%; p = 0.014) and the need for post-operative inotropic or mechanical support (12 vs 26%; p = 0.021) [135]. Peri-operative allopurinol treatment (300–600 mg/day for 5 days) also reduced the risk of cardiac complications, including arrhythmias (p < 0.01), MI (p < 0.01) and requirement for intra-aortic balloon pump support (p = 0.05) [136]. On the contrary, other studies failed to show benefit with allopurinol treatment.
Allopurinol as a therapeutic option in cardiovascular disease
2017, Pharmacology and TherapeuticsCitation Excerpt :These ‘leaked’ electrons combine with molecular oxygen to form superoxide anions (Burgoyne et al., 2013). Recognition of the importance of XO-derived ROS generation has prompted the evaluation of allopurinol in clinical models of IRI (Table 1 (Bochenek et al., 1990; Castelli et al., 1995; Coetzee, Roussouw, & Macgregor, 1996; Coghlan et al., 1994; Gimpel, Lahpor, van der Molen, Damen, & Hitchcock, 1995; Guan et al., 2003; Johnson, Kayser, Brenowitz, & Saedi, 1991; Movahed, Nair, Ashavaid, & Kumar, 1996; Parmley, Mufti, & Downey, 1992; Rashid & William-Olsson, 1991; Rentoukas et al., 2010; Sisto et al., 1995; Tabayashi et al., 1991; Taggart et al., 1994; Talwar et al., 2010)). In a randomised, placebo-controlled trial of 169 patients undergoing elective coronary artery bypass grafting (CABG) (Johnson et al., 1991), which has previously been shown to result in oxidative stress upon reperfusion (Chambers, 2007; Zakkar, Guida, Suleiman, & Angelini, 2015), the use of oral allopurinol reduced in-hospital mortality (4 vs. 18%, p = 0.014) and the need for post-operative inotropic or mechanical support (12 vs. 26%, p = 0.021).
Comparison between warm blood and crystalloid cardioplegia during open heart surgery
2003, International Journal of CardiologyEffect of preoperative administration of allopurinol in patients undergoing surgery for valvular heart diseases
2010, European Journal of Cardio-thoracic SurgeryThe increase in serum uric acid concentration caused by diuretics might be beneficial in heart failure
2005, European Journal of Heart Failure