Enhancement of acetaldehyde-protein adduct formation by l-ascorbate
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2002, Chemico-Biological InteractionsCitation Excerpt :Schiff base formation has been proposed for the aldehyde metabolite of Sorbinil, which shows an incidence of hypersensitivity [9], and for ethanol, in which acetaldyde formation is proposed to underlay the immune hepatitis observed with chronic alcohol consumption [10]. The reversibility of this Schiff base formation has been proposed to be limited either by reduction by ascorbate [11], or for acetaldehyde, cyclization with an amide nitrogen of the protein to form a stable imidazolidinone [12]. Thus mechanisms may exist in vivo for the stabilization of these somewhat unstable adducts.
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