Leukotriene B4 augments human natural cytotoxic cell activity

https://doi.org/10.1016/0006-291X(83)91758-8Get rights and content

Abstract

We have recently shown that leukotriene B4 (LTB4) activates T lymphocytes to become suppressor cells. We now report that LTB4 also augments human natural cytotoxic cell activity against target cells infected with herpes simplex virus. This activity is partially inhibited by the lipoxygenase inhibitor nordihydroguaiaretic acid and the thromboxane synthetase inhibitor OKY-1581, but is augmented by indomethacin. We suggest that LTB4 may play a role in early host defense responses during inflammatory and infectious disease processes.

References (16)

  • P. Borgeat et al.

    J. Biol. Chem

    (1979)
  • M. Rola-Pleszczynski et al.

    Biochem. Biophys. Res. Comm

    (1982)
  • M. Rola-Pleszczynski et al.

    Cell. Immunol

    (1981)
  • E. Reinherz et al.

    Cell

    (1980)
  • S. Kohl et al.

    Prostagl. Leukotr. Med

    (1982)
  • H.S. Koren et al.

    Molecul. Immunol

    (1982)
  • P. Sirois et al.

    Prostagl. Leukotr. Med

    (1982)
  • P. Sirois et al.
There are more references available in the full text version of this article.

Cited by (121)

  • LTB4 increases nasal neutrophil activity and conditions neutrophils to exert antiviral effects

    2011, Respiratory Medicine
    Citation Excerpt :

    Original findings on the biology of this leukotriene comprise demonstrations of its biosynthesis by, and its potent chemotactic and activating effects on, polymorpho-nuclear leukocytes .1–3 Accordingly, and substantiated by a series of subsequent observations,4–11 LTB4 is regarded as a key mediator of the innate immune system. Information on the role of LTB4 in human airways can be obtained through experiments involving airway challenges with this leukotriene.

  • Cysteinyl-leukotrienes and the liver

    2003, Prostaglandins and Other Lipid Mediators
  • BLT1 and BLT2: The leukotriene B<inf>4</inf> receptors

    2003, Prostaglandins Leukotrienes and Essential Fatty Acids
View all citing articles on Scopus
View full text