Biochemical and Biophysical Research Communications
Abundance of endothelin-3 in rat intestine, pituitary gland and brain
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2020, Seminars in PerinatologyCitation Excerpt :ETA mediates vasoconstriction by stimulating cytosolic calcium release on pulmonary arterial smooth muscle cells, while ETB causes vasodilation by stimulating the release of prostacyclin and nitric oxide. Normally, the pulmonary vasculature has the highest levels of ET-1 in the body, and patients with PH usually have elevated levels of ET-1 in their lungs and pulmonary vasculature.19–21 Additionally, studies have found that, in PH, there is an imbalance of endothelin receptors, where a predominance of ETA compared to ETB exists.
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2019, PlacentaCitation Excerpt :ET-1 is known to be highly involved in uterine blood flow regulation and critical for the development of preeclampsia [17]. ET-2 is mainly expressed in intestines and ovaries [18], while ET-3 is highly expressed in the brain and intestinal tract [19] but also in vagina and endometrium [20]. All three ET isoforms are expressed in the female reproductive organs suggesting that they play a role in the paracrine control of the uterine vasculature [20].
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