Biochemical and Biophysical Research Communications
Volume 159, Issue 1, 28 February 1989, Pages 126-131
Regulation of epidermal growth factor-receptor by estrogen and antiestrogen in the human breast cancer cell line MCF-7
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2012, Biochimica et Biophysica Acta - General SubjectsCitation Excerpt :The estrogen receptor (ER) and the progesterone receptor (PR) belong to the steroid hormone receptor family of ligand inducible transcription factors [5]. These hormones play important roles in the control of proliferation and differentiation of breast cells, but other tissue components and growth factors may also be involved, underlining the complexity of these control mechanisms [6–8]. In all animal tissues, the cells are located in a microenvironment composed of a dynamic and complex array of collagens, glycoproteins, proteoglycans (PGs) and glycosaminoglycans (GAGs)—the extracellular matrix.
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Copyright © 1989 Published by Elsevier Inc.