Biochemical and Biophysical Research Communications
Selectin GMP-140 (CD62; PADGEM) binds to sialosyl-Lea and sialosyl-Lex, and sulfated glycans modulate this binding
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Raft microdomain localized in the luminal leaflet of inner membrane complex of living Toxoplasma gondii
2021, European Journal of Cell BiologyCitation Excerpt :It has also been reported that the extracellular matrix controls the function of microdomains in the exoplasmic leaflet of the plasma membrane in some mammalian cells (Edidin, 2003; Ritchie et al., 2003; Mukherjee and Maxfield, 2004). Additionally, glycosphingolipids including GM3, which are major compartments of raft microdomains, were reported to play roles in cell adhesion and cell signal transductions by binding to integrin receptors, such as α5β1 and αvβ3 (Cheresh et al., 1987; Zheng et al., 1993), selectins (Handa et al., 1991, 1997), galectins (Collins et al., 2014), and other carbohydrate-binding proteins (Hattori et al., 1995; Yang et al., 1996; Taki et al., 1997). Accordingly, it has been well known that GM3 in the plasma membrane has many functions via the interaction with the extracellular components.
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