Lipid peroxide level in plasma of diabetic patients
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Synergistic effect of quercetin and quinic acid by alleviating structural degeneration in the liver, kidney and pancreas tissues of STZ-induced diabetic rats: A mechanistic study
2014, Food and Chemical ToxicologyCitation Excerpt :In addition, the QEa + QAa combined treatment attenuated the disorder of lipid metabolism, similarly to the effect observed in the study conducted by Wang et al. (2012). It has been pre-clinically and clinically proven that the level of lipid peroxidation is significantly increased in the plasma of diabetic rats and diabetic patients (Sato et al., 1979). Furthermore, lipid peroxidation, which is a free radical-mediated oxidation of polyunsaturated fatty acids, is increased in the DC group, as is evident from the elevated MDA levels.
Naringenin accords hepatoprotection from streptozotocin induced diabetes in vivo by modulating mitochondrial dysfunction and apoptotic signaling cascade
2014, Toxicology ReportsCitation Excerpt :The prevalence and mortality due to this chronic metabolic disease have been reported in both developed and developing countries. Though the leading mechanism of diabetic complications remains unclear, oxidative damage is considered as one of the major causative factors [12,32,33]. Scientific reports show enhanced generation of reactive oxygen species (ROS) in both types of diabetes (Type-1 and Type-2), which relates oxidative stress to the onset of diabetes [10].
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2023, Nature CommunicationsEffect of madecassoside in reducing oxidative stress and blood glucose in streptozotocin-nicotinamide-induced diabetes in rats
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