Alamine aminopeptidase excretion after mercuric chloride renal failure

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Abstract

Within the first 24 hr after induction of acute renal failure in rats by 4.7 mg/kg body weight of mercuric chloride, there was a highly significant (P < 0.001) increase in urine AAP activity. Enzymuria sharply declined during the next 48 hr, although did not return to baseline until Day 4. A transient secondary period of hyperenzymuria occurred 8 to 10 days after injection. In addition to the type of renal injury, timing of sample collections influences the diagnostic value of urine enzyme determinations.

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