Metabolism of dihalomethanes to carbon monoxide—III: Studies on the mechanism of the reaction☆
References (36)
- et al.
Toxic. app. Pharmac.
(1975) - et al.
Toxic app. Pharmac.
(1977) - et al.
Toxic. app. Pharmac.
(1977) Archs Biochem. Biophys.
(1968)- et al.
Biochem. Med.
(1975) - et al.
J. biol. Chem.
(1951) - et al.
Biochem. Pharmac.
(1969) - et al.
Biochem. biophys. Res. Commun.
(1973) - et al.
Biochem. biophys. Res. Commun.
(1974)
Fedn Eur. Biochem. Soc. Lett.
Biochem. biophys. Res. Commun.
Biochem. biophys. Res. Commun.
Science N.Y.
Archs envir. Hlth
StaubReinhalt. Luft
Drug Metab. Dispos.
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2021, Regulatory Toxicology and PharmacologyCitation Excerpt :Biotransformation is multifaceted and yields both stable and chemically reactive metabolites responsible for most toxic effects of DCM. Two competitive pathways of biotransformation of DCM have been identified in animals (Fig. 1), i) oxidation of DCM by cytochrome P450 and ii) conjugation of DCM by glutathione S-transferases (Kubic et al., 1974; Ahmed and Anders, 1976; Kubic and Anders, 1978; Green, 1983). Both pathways of DCM-biotransformation differ significantly in the chemical reactivity of the products formed and in their kinetic properties.
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2020, Toxicology LettersCitation Excerpt :Interestingly, in H9c2 rat cardiomyocytes similar effects were observed following dichloromethane (DCM) treatment (Suliman et al., 2007). DCM undergoes cytochrome P450-mediated metabolism, thereby producing CO as a by-product (Pankow and Jagielki, 1993, Kubic and Anders, 1978). However, it should be taken into account that xenobiotic metabolism of DCM also leads to the formation of other metabolites, possibly interfering with CO-related read outs.
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This research was supported by U.S.P.H.S. National Institutes of Health Grant ES 01082.