Characterization of histamine H-1 receptors on human peripheral lung
References (32)
- et al.
J. Allergy clin. Immun.
(1984) - et al.
Eur. J. Pharmac.
(1981) - et al.
Biochim. biophys. Acta
(1980) - et al.
J. invest. Derm.
(1976) - et al.
J. Allergy clin. Immunol.
(1979) - et al.
J. biol. Chem.
(1951) - et al.
Life Sci.
(1983) - et al.
Analyt. Biochem.
(1980) - et al.
J. exp. Med.
(1967) - et al.
J. exp. Med.
(1968)
Invest. radiol.
J. Pharmac. exp. Ther.
Naunyn-Schmiedeberg's Archs Pharmac.
Agents Action
Envir. Hlth. Perspect.
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Antihistaminic and antiallergic actions of extracts of Solanum nigrum berries: Possible role in the treatment of asthma
2012, Journal of EthnopharmacologyCitation Excerpt :Asthma is the common chronic inflammatory disease of the airways characterized by variable and recurring symptoms, reversible airflow obstruction, and bronchospasm. Histamine is present in the mucosa of human nasal turbinates and lung (Casale et al., 1985) which is responsible for bronchoconstrictive responses (Herxheimer, 1949; Wood-Baker and Holgate, 1993; Schmidt et al., 1999). The pathophysiology of asthma is complex and involves the following components: airway inflammation, intermittent airflow obstruction and bronchial hyperresponsiveness.
Mepyramine, a histamine H<inf>1</inf> receptor inverse agonist, binds preferentially to a G protein-coupled form of the receptor and sequesters G protein
2004, Journal of Biological ChemistryCitation Excerpt :Interestingly, saturation binding experiments disclosed two binding sites for mepyramine (p < 0.05, F test), one with higher affinity (0.16 ± 0.02 nm) and lower capacity (32.8 ± 2.8 fm/mg of protein) and a second one with lower affinity (2.4 ± 0.4 nm) and higher capacity (445.8 ± 19.9 fm/mg of protein). This is consistent with previous observations from several other groups (18–20). Most of the ligands previously classified as H1 antagonist were recently reclassified as inverse agonists in view of the reported constitutive activity of the human histamine H1 receptor (10).
H<inf>1</inf>-Receptors: Localization and role in airway physiology and in immune functions
2003, Journal of Allergy and Clinical ImmunologyDesloratadine inhibits allergen-induced airway inflammation and bronchial hyperresponsiveness and alters T-cell responses in murine models of asthma
2003, Journal of Allergy and Clinical ImmunologyRole of histamine in the pathophysiology of asthma: Immunomodulatory and anti-inflammatory activities of H<inf>1</inf>-receptor antagonists
2002, American Journal of MedicineCitation Excerpt :The H1 receptor possesses all of the structural features of G-protein–coupled receptors, including 7 transmembrane domains, amino terminal glycosylation sites, and protein kinase A and protein kinase C phosphorylation sites.9 H1 receptors have been detected in the mammalian brain,10 airway smooth muscle,11,12 gastrointestinal tract,13 genitourinary system,14 vascular smooth muscle,15 endothelial cells,5 monocytes/macrophages, and lymphocytes.3,16 In general, allergic/inflammatory responses are mediated by means of H1 receptors,17 and therefore H1-receptor antagonists block many of the consequences of histamine release.1
Histamine and serotonin
2001, Pulmonary Pharmacology and Therapeutics