Drug-protein conjugates—VIII The metabolic fate of the dinitrophenyl hapten conjugated to albumin☆
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Cited by (27)
Evaluation of radioiodinated protein conjugates and their potential metabolites containing lysine-urea-glutamate (LuG), PEG and closo-decaborate(2-) as models for targeting astatine-211 to metastatic prostate cancer.
2021, Nuclear Medicine and BiologyCitation Excerpt :Compounds 9a and 16a, which contain conjugated N-acetyl lysine moieties, were synthesized, radioiodinated and evaluated in vivo. It should be noted that some metabolites of protein conjugates have previously been shown to contain a N-acetyl lysine moiety [39]. The results from that animal study showed a large difference in tumor localization between 16a, which had a prostate cancer-targeting LuG moiety, and 9a, which did not contain a LuG moiety (Fig. 5).
Mechanistic role of acyl glucuronides
2013, Drug-Induced Liver DiseaseHalothane metabolism: Kupffer cells carry and partially process trifluoroacetylated protein adducts
1991, Biochemical and Biophysical Research Communications
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For part VII in the series “Drug-Protein Conjugates” see P. S. Grabowski and B. K. Park, Biochem. Pharmac.33, 3289 (1984).
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Wellcome Senior Lecturer.
Copyright © 1985 Published by Elsevier Inc.