Selective inhibition of cyclic nucleotide phosphodiesterases of human, bovine and rat aorta
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2020, Pharmacology and TherapeuticsCitation Excerpt :Binding of a specific region in the N-terminus of the R subunits to A-kinase anchoring proteins (AKAPs) targets PKA activity to specific subcellular membranes and multiprotein complexes (Ercu & Klussmann, 2018). Of note, the concentration of cAMP in vascular tissues is usually ≈ 5 times higher than cGMP (Lugnier, Schoeffter, Le Bec, Strouthou, & Stoclet, 1986) although relative levels can show great variability. Intracellular levels of cAMP and cGMP are mitigated by the activity of PDEs, a large group of enzymes which in mammals is composed of 11 families that encompass 21 genes and multiple variants (see reviews by (Bobin et al., 2016; Keravis & Lugnier, 2012; Maurice et al., 2014)).
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2019, European Journal of Medicinal ChemistryCitation Excerpt :PDE1, PDE3, PDE4 and PDE5 were isolated by anion exchange chromatography from bovine aortic smooth muscle cytosolic fraction according to the literature [3]. PDE2 was isolated from human platelets following the methods indicated in the literature [2,3]. Purified PDEs were stored until use at −80 °C in small aliquots (200 μL).