Carbon monoxide relaxes ileal smooth muscle through activation of guanylate cyclase
References (38)
Effect of PGI2 and stable endoperoxide analogues on cyclic nucleotide levels in clonal cell lines of CNS origin
FEBS Lett
(1978)- et al.
Measurement of protein using Bicinchonic Acid
Anal Bioch
(1985) - et al.
Soluble guanylate cyclase purified from bovine lung contains heme and copper
FEBS Lett
(1981) - et al.
Cytochrome c Oxidase components
J Biol Chem
(1963) - et al.
Photochemical action spectra of carbon monoxide-inhibited respiration
J Biol Chem
(1955) - et al.
Studies on cytochrome oxidase
J Biol Chem
(1963) - et al.
The reaction of cytochrome oxidase with carbon monoxide
J Biol Chem
(1951) - et al.
Carbon monoxide inhibits depolarization-induced Ca rise and increases cyclic GMP in visceral smooth muscle cells
Biochem Pharmacol
(1991) - et al.
Modulation of cyclic guanosine monophosphate levels in cultured aortic smooth muscle cells by carbon monoxide
Biochem Pharmacol
(1989) - et al.
Regulation of intracellular Ca2+ levels in cultured vascular smooth muscle cells
J Biol Chem
(1989)
Mechanism of cyclic GMP inhibition of inositol phosphate formation in rat aorta segments and cultured bovine aortic smooth muscle cells
J Biol Chem
Carbon monoxide effects on calcium levels in vascular smooth muscle
Life Sci
Guinea pig ductus arteriosus. I. Cellular and metabolic basis for oxygen sensitivity
Am J Physiol
Cytochrome P450-linked monooxygenase: involvement in the lamb ductus arteriosus
Am J Physiol
Role of cytochrome P450 in alveolar hypoxic pulmonary vasoconstriction in dogs
J Clin Invest
Is carbon monoxide a calcium blocking agent? I. Effect of carbon monoxide on mechanical tension in isolated thoracic aorta
Mechanism of carbon monoxide toxicity
Prev Med
Response of rat coronary circulation to carbon monoxide and nitrogen hypoxia
Studies on the mechanism of carbon monoxide-induced vasodilation in the perfused heart
Toxicol Appl Pharmacol
Cited by (115)
Hemoglobin: Multiple molecular interactions and multiple functions. An example of energy optimization and global molecular organization
2022, Molecular Aspects of MedicineEmerging role of carbon monoxide in intestinal transplantation
2021, Biomedicine and PharmacotherapyApplication of carbon monoxide in kidney and heart transplantation: A novel pharmacological strategy for a broader use of suboptimal renal and cardiac grafts
2021, Pharmacological ResearchCitation Excerpt :Since then, growing experimental evidence has changed the negative public image of CO, suggesting a rapid paradigm shift in which low concentrations produce therapeutic effects including antioxidant, anti-inflammatory, anti-apoptotic, anti-fibrotic, anti-thrombotic, anti-proliferative and vasodilatory effects. Indeed, low physiological concentrations of CO stimulate vascular signaling and relaxation by activating soluble guanylate cyclase (sGC), an enzyme that converts guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP) to mediate vascular and other biological effects of CO [12,13]. It is important to note that direct application of CO to vascular smooth muscle cells also produces cGMP, whose downstream vasodilatory effect increases tissue perfusion and confers cytoprotection under hypoxic condition and during ischemia-reperfusion injury (IRI) as well as during inflammation-induced tissue injury [14,15].
A brief history of carbon monoxide and its therapeutic origins
2021, Nitric Oxide - Biology and ChemistryCitation Excerpt :Throughout the gastrointestinal tract, CO is a gasotransmitter produced by HMOX2 where it is essential for motility [225]. The most widely known mechanism of action for CO is that of vasodilation via activation of soluble guanyl cyclase (likewise well-established for NO) [226]. Trace evidence for this physiological signaling mechanism can be traced back to 1865 when Klebs observed dilation of cranial blood vessels in Effect of Carbon Monoxide on the Animal Organism [44].
Inhaled carbon monoxide increases vasodilation in the microvascular circulation
2019, Microvascular ResearchBiological signaling by small inorganic molecules
2016, Coordination Chemistry ReviewsCitation Excerpt :NO can upregulate HO-1 expression thus increasing endogenous levels of CO, while CO can regulate iNOS expression and activity [376,377]. As mentioned above, CO can also activate sGC leading to smooth muscle relaxation [378]. Based on their interrelationship and the similar roles of CO and NO, CO is speculated to substitute for NO under NO-deficient conditions and to regulate the bioavailability of NO.