Elsevier

Biochemical Pharmacology

Volume 42, Issue 1, 21 June 1991, Pages 195-198
Biochemical Pharmacology

Short communication
Murine strain differences in pulmonary bleomycin metabolism

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    The lung function changes we observed were similar to that observed by Vanoirbeek et. al. in their bleomycin Balb/c mouse model for H and E [15], even though it has been reported that the Balb/c strain has increased activity of the bleomycin detoxifying enzyme bleomycin hydrolase [16]. Their absolute values for E and H are also considerably lower than ours due to the different strain of mice used in their bleomycin model.

  • Predisposition for disrepair in the aged lung

    2012, American Journal of the Medical Sciences
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    We believe that this is caused by a profibrotic phenotype present in old lungs, which is characterized by increased expression of TGF-β1, TGF-βR1 and Smad3 and increased expression of the Fn-EDA splice variant and MMPs. Other potential mechanisms involved in the development of fibrosis in the bleomycin model relate to the tissue expression of bleomycin hydrolase (BH).43 Currently, there are no published studies examining the activity or level of BH in aged tissues.

  • Genetic Susceptibility To Late Normal Tissue Injury

    2007, Seminars in Radiation Oncology
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    A tissue that has generated a great deal of interest not only in the radiation field but in the pulmonary field itself is genetic susceptibility to lung diseases such as asthma,36,37,40,41 chronic obstructive pulmonary disease,42 idiopathic pulmonary fibrosis,43,44 and ozone.20,24,45,46 In humans, exposure to known etiological agents does not always produce fibrosis (eg, in radiation and bleomycin-induced lung fibrosis); a wide variation in response is seen in humans47-49 as well as animal models29,50-54 that cannot be totally accounted for by known risk factors. Using genome-wide linkage analysis, a body of data now exists in mouse models from our laboratory and others that shows that radiation-induced lung fibrosis is a heritable trait controlled by a few genetic factors.13,15,16,18,19,29

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