Importance of the paracellular pathway for the transport of a new bisphosphonate using the human CACO-2 monolayers model
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2019, Journal of Drug Delivery Science and TechnologyCitation Excerpt :By specifically attaching to tumor cell recognizing ligands on NPs, the drug can be preferentially endocytosed to achieve effective tumor targeted therapy. Bisphosphonate has long been regarded as an active bone-seeking agent which possesses great affinity to the abundant hydroxyapatite in bone environments [16,17]. Moreover, protein tyrosine phosphatases, which are overexpressed on the osteosarcoma cell surface [18], represent one of the bisphosphonate specific receptors.