Elsevier

Biological Psychiatry

Volume 38, Issue 4, 15 August 1995, Pages 263-266
Biological Psychiatry

Brief report
Effects of cocaine on D3 and D4 receptor expression in the human striatum

https://doi.org/10.1016/0006-3223(95)00099-3Get rights and content

First page preview

First page preview
Click to open first page preview

Cited by (24)

  • Abstinence to chronic methamphetamine switches connectivity between striatal, hippocampal and sensorimotor regions and increases cerebral blood volume response

    2018, NeuroImage
    Citation Excerpt :

    One study in humans that examined protein levels rather than receptor binding found a large increase in D1R in accumbens in methamphetamine addicts, but only a non-significant trend towards a decrease in D2R (Worsley et al., 2000). Studies in humans have found increased D3R (Staley and Mash, 1996) or no change (Meador-Woodruff et al., 1995). In vivo human studies of D3R using the PET ligand [11C]-(+)-PHNO in psychostimulant abusers shows increased D3R in globus pallidus and substantia nigra (reviewed in (Boileau et al., 2015)), though these studies, like those here, can be confounded by the fact that the Bmax for D2R is much higher than for D3R (except in accumbens) and since D2R goes down and D3R goes up the mixed selectivity for D2R/D3R for most ligands can confound the in vivo studies (see a discussion of this issue in (Choi et al., 2010) and Jenkins, 2012)).

  • D<inf>3</inf> dopamine receptors are down-regulated in amphetamine sensitized rats and their putative antagonists modulate the locomotor sensitization to amphetamine

    2003, Brain Research
    Citation Excerpt :

    Our current finding that both D3 mRNA and protein levels decreased in the behaviorally sensitized animals seems to support the notion that D3 receptors are negatively coupled to activation of locomotor activity. In addition, our results appear to be comparable with previous study that binding of D3 receptors decreased in cocaine-addicted animals [45]; but in contrast with others that reported no change [23] or increase in D3 receptor binding [37,41] in cocaine-abused human victim. Considering the drug schedule would affect greatly the degree and pattern of behavioral sensitization, the discrepancy between ours and others [15] could most likely due to the difference in drug doses, frequency of drug injection, withdrawal time or specific brain regions.

View all citing articles on Scopus

This work was also supported by MH42251 (SJW) and The Foundation of Hope for Research and Treatment of Mental Illness (KYL).

1

Dr. Meador-Woodruff is the recipient of a Research Scientist Development Award from NIMH (MH00818).

View full text