Elsevier

Brain Research

Volume 168, Issue 2, 25 May 1979, Pages 425-429
Brain Research

Effects of morphine on intracranial self-stimulation to various brain stem loci

https://doi.org/10.1016/0006-8993(79)90187-2Get rights and content

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  • The potential anti-addictive agent, 18-methoxycoronaridine, blocks the sensitized locomotor and dopamine responses produced by repeated morphine treatment

    2000, Brain Research
    Citation Excerpt :

    Such findings indicate that repeated morphine administration increases an animal’s sensitivity to the effects of ibogaine on morphine-induced locomotion. The repeated, intermittent, administration of morphine can induce a progressive decrease in the latency to onset of morphine’s locomotor-activating effects [1,4,13,24,25,58], an effect putatively mediated by an enhancement in mesotelencephalic dopamine (for review see [29]). Termed, sensitization (for review, [50]), this phenomenon has been theorized by some authors to lie at the very core of both drug craving and relapse in drug addiction, e.g., [28,51].

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Supported in part by NIDA Grant DA 00377, NIMH NRSA Biological Science Training Program Award MH 15189 to R.U.E. and NIMH Research Scientist Award, MH 1759 to C.K.

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