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The 5-HT<inf>3</inf> antagonist Y-25130 blocks cocaine-induced lowering of ICSS reward thresholds in the rat
2003, Pharmacology Biochemistry and BehaviorThe potential anti-addictive agent, 18-methoxycoronaridine, blocks the sensitized locomotor and dopamine responses produced by repeated morphine treatment
2000, Brain ResearchCitation Excerpt :Such findings indicate that repeated morphine administration increases an animal’s sensitivity to the effects of ibogaine on morphine-induced locomotion. The repeated, intermittent, administration of morphine can induce a progressive decrease in the latency to onset of morphine’s locomotor-activating effects [1,4,13,24,25,58], an effect putatively mediated by an enhancement in mesotelencephalic dopamine (for review see [29]). Termed, sensitization (for review, [50]), this phenomenon has been theorized by some authors to lie at the very core of both drug craving and relapse in drug addiction, e.g., [28,51].
Low-dose apomorphine attenuates morphine-induced enhancement of brain stimulation reward
1996, Pharmacology Biochemistry and BehaviorChronic morphine fails to enhance the reward value of prefrontal cortex self-stimulation
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Supported in part by NIDA Grant DA 00377, NIMH NRSA Biological Science Training Program Award MH 15189 to R.U.E. and NIMH Research Scientist Award, MH 1759 to C.K.