The opiate antagonist naloxone modifies the effects of electroconvulsive shock (ECS) on respiration, blood pressure and heart rate
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Electrical Stimulation Seizure Models
2017, Models of Seizures and Epilepsy: Second EditionRespiratory effects of buprenorphine/naloxone alone and in combination with diazepam in naive and tolerant rats
2014, Toxicology LettersCitation Excerpt :Interestingly, NLX infusion has also been demonstrated to increase oxygen consumption (Malin et al., 1985). However, this enhanced ventilatory response to NLX was disputed in other experimental studies showing no significant effects in rat (Baraban et al., 1993; Belenky and Holaday, 1979; Dai et al., 1983; Malin et al., 1985; Steinbrook et al., 1984). In our study, modifications induced by NLX co-administration to BUP-related plethysmography effects could additionally be attributed to a certain degree of competition between both molecules at the opioid receptors, although BUP affinity exceeded naloxone's at all opioid-receptor types (inhibitory constant 0.08 nM for BUP vs. 0.93 nM for NLX, regarding mu-opioid receptors) (Emmerson et al., 1994; Raynor et al., 1994).
Cardiovascular dysautonomia after seizures induced by maximal electroshock in Wistar rats
2012, SeizureCitation Excerpt :Similarly, Darbin and Naritoku6 found that changes in neurocardiac regulation occur in the immediate postictal phase following MES, with a transient, markedly irregular heart rhythm. Belenky and Holaday19 demonstrated that electroconvulsive Shock (ECS) produces a significant fall in mean arterial pressure (MAP) and HR 20–40 s post-ECS followed by hypertension. The bradycardia after the seizure strongly suggests the involvement of the autonomic nervous system.
The antidepressant-like effect of human opiorphin via opioid-dependent pathways in mice
2011, Neuroscience LettersThe neurophysiology of concussion
2002, Progress in NeurobiologyCitation Excerpt :It has long been recognized that the symptoms of concussion appear to overlap those of a generalized epileptic seizure to a remarkable degree (Symonds, 1935; Kooi, 1971; Symonds, 1974; Plum and Posner, 1980). Likewise, the similarity between patients who have been concussed and those who have received electroconvulsive therapy (ECT) has often been noticed (Brown and Brown, 1954; Clare, 1976; Parkinson, 1982), as well as that between animals which have been administered ECS and those which have been experimentally concussed (Brown and Brown, 1954; Belenky and Holaday, 1979; Urca et al., 1981; Hayes et al., 1989). These types of observations have fuelled a lingering but rather inchoate suspicion that the pathophysiological events underlying ictal and post-ictal states may be related to concussion.
Involvement of δ-opioid receptors in the effects induced by endogenous enkephalins on learned helplessness model
1998, European Journal of Pharmacology
The views of the authors do not purport to reflect the positions of the Department of the Army or the Department of Defense. (Para. 4-3, AR 360-5).