Aromatization of androgen to estrogen by cultured turtle brain cells
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Cited by (22)
You've got male: Sex and the microbiota-gut-brain axis across the lifespan
2020, Frontiers in NeuroendocrinologyCitation Excerpt :Prolonged conjugated oestrogen supplementation causes reduction in gut microbiota beta-glucuronidase activity without modulating the gut composition (Chen et al., 2018b). Further androgens are converted to oestrogens via the aromatase enzyme, expressed locally in neurons and brain cells (Callard et al., 1980), thus developmental regulation of aromatase activity in males and females can also impact synaptic plasticity and neuronal circuit dynamics (Bender et al., 2017; Lu et al., 2019a,b). It is thus interesting to ask whether aromatase activity may also be modulated by the gut microbiota.
Multiple sclerosis: Neuroprotective alliance of estrogen-progesterone and gender
2012, Frontiers in NeuroendocrinologyCitation Excerpt :The aromatase is another critical and highly regulated enzymatic site to control E formation (for additional information about the exact synthetic and regulatory pathways see Geneva Foundation for Medical Education and Research, http://gfmer.ch/Books/Reproductive_health/Steroid_hormone_metabolism.html). It has been demonstrated more than 40 years ago in various animals including rodents and birds that the brain itself is an additional important source for local estrogens [33] and represents a target for steroid hormones involving steroid receptors which, at that time, had not yet been detected [146]. However, already another 25 years before that, first effects of E on neurotransmitter systems in the CNS have been reported [146].
Localization and expression of aromatase mRNA in adult zebrafish
2004, General and Comparative EndocrinologyThe microsomal mixed function oxidase system of amphibians and reptiles: Components, activities and induction
1998, Comparative Biochemistry and Physiology - C Pharmacology Toxicology and EndocrinologyMetabolism of steroids in the brain: A new insight into the role of 5α-reductase and aromatase in brain differentiation and functions
1996, Journal of Steroid Biochemistry and Molecular BiologyExtraction and separation of androstenedione from products of aromatase assays on micro-columns of magnesium oxide
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