Sensory neurotoxins: Chemically induced selective destruction of primary sensory neurons
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Neuropeptides in Immunoregulation
2016, Insights to Neuroimmune Biology: Second EditionEffects of electroacupuncture on capsaicin-induced model of atopic dermatitis in rats
2014, Journal of Dermatological ScienceCitation Excerpt :When neurodegenerative changes occur, a massive amount of neuropeptides such as substance P are released, resultsing in the depletion of the neuropeptides at the nerve endings, and thereby causing long-term neurotransmission injury [22]. Capsaicin induces neurodegenerative changes when it is injected within 1–12 days after birth and no neurodegenerative changes are observed when it is given after 14 days [24]. Thus, rat pups within 48 h of birth were used in the present experiment.
Capsaicin prevents the hyperalgesia induced by peripheral group I mGluRs activation
2011, Neuroscience LettersPlasticity of nodose ganglion neurons after capsaicin- and vagotomy-induced nerve damage in adult rats
2010, NeuroscienceCitation Excerpt :After nerve injury, “staggered” outgrowth refers to the property of axons to grow with different onsets and rates. It has been reported that capsaicin-induced degeneration in the dorsal horn of the spinal cord and in the brain stem (Jancsõ and Kiraly, 1980, 1981; Dinh and Ritter, 1987) reflects degeneration of the central endings of primary afferent neurons (Holzer, 1991). Ritter and Dinh (1988) reported that this degeneration may be long-lasting in adult rats.
Neurogenic Vascular Responses in the Dura Mater and their Relevance for the Pathophysiology of Headaches
2009, NeuroImmune BiologyCitation Excerpt :In various tissues, a population of chemosensitive neurons containing CGRP, SP, and NKA has been described giving rise to polymodal C-fiber and Aδ mechano-heat nociceptors. Capsaicin (8-methyl-N-vanillyl-6-nonenamide), the pungent agent of red pepper, selectively stimulates the chemosensitive neuron population and, after repeated application, functionally inactivates these capsaicin-sensitive neurons [34–39]. Selective denervation with loss of capsaicin-sensitive neurons reduced the SP-like immunoreactivity in the rat trigeminal ganglion [40].