Research reportThe regional distribution of somatostatin, substance P and neurotensin in human brain
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Matching of the postmortem hypothalamus from patients and controls
2021, Handbook of Clinical NeurologyCitation Excerpt :However, synaptophysin immunocytochemistry was decreased significantly in mouse neocortex and hippocampus when the brain was stored for 4 h at 22°C instead of 4°C to mimic postmortem conditions that occur in human situation (Hilbig et al., 2004). In contrast, several neuropeptides and receptors remain very stable over the period of several days (Cooper et al., 1981). Hypothalamic TRH levels remain stable from 2.5 and 21 h postmortem (Parker Jr. and Porter, 1982).
Are periaqueductal gray and dorsal raphe the foundation of appetitive and aversive control? A comprehensive review
2019, Progress in NeurobiologyThe role of intraamygdaloid neurotensin and dopamine interaction in conditioned place preference
2018, Behavioural Brain ResearchCitation Excerpt :NT is widely distributed in the mammalian central nervous system, where it acts as a neurotransmitter and neuromodulator [2,3]. High concentrations of NT were shown in the substantia nigra, nucleus accumbens (NAC), hypothalamus, periaqueductal gray matter and amygdala (AMY) [2,4–6]. Numerous NT-containing pathways have been identified to be originating from the ventral tegmental area (VTA), amygdala (AMY) and subiculum [7,8].
The art of matching brain tissue from patients and controls for postmortem research
2018, Handbook of Clinical NeurologyRepeated effects of the neurotensin receptor agonist PD149163 in three animal tests of antipsychotic activity: Assessing for tolerance and cross-tolerance to clozapine
2014, Pharmacology Biochemistry and BehaviorAn autoradiographic study of neurotensin receptors in the human hypothalamus
2014, Acta HistochemicaCitation Excerpt :The involvement of NTergic neurons in the regulation of neuroendocrine secretion has been supported by numerous observations. High NT endogenous levels have been detected in the hypothalamic region of both the rat and human as demonstrated by radioimmunoassay (Uhl and Snyder, 1976; Cooper et al., 1981; Manberg et al., 1982). NT-immunoreactive (IR) cell bodies have also been seen in many hypothalamic structures such as the paraventricular and infundibular nuclei, which send their fibers to the median eminence (Merchenthaler and Lennard, 1991).