Histamine H1 receptors in human brain labelled with [3H]Doxepin
Reference (21)
- et al.
Histamine synthesizing afferents within the amygdaloid complex and bed nucleus of the stria terminalis of the rat
Brain Research
(1977) - et al.
Membrane receptors and hormone actions
Advanc. Protein Chem.
(1976) Mathematical theory of complex ligand binding systems at equilibrium: some methods for parameter fitting
Analyt. Biochem.
(1972)- et al.
Tricyclic antidepressants: potent blockade of histamine H1-receptors of guinea pig ileum
Europ. J. Pharmacol.
(1979) - et al.
Central actions of histamine: microelectrophoretic studies
Brain Research
(1977) - et al.
Antidepressants are weak competitive antagonists of histamine H2 receptors in dissociated brain tissue
Europ. J. Pharmacol.
(1983) - et al.
Protein measurement with the Folin phenol reagent
J. biol. Chem.
(1951) - et al.
Ligand: a versatile computerized approach for characterization of ligand-binding system
Analyt. Biochem.
(1980) - et al.
Interaction between mianserin, an antidepressant drug and central H1- and H2-histamine-receptors: in vitro and in vivo studies and radio receptor assay
Neuropharmacology
(1983) - et al.
Histamine receptors in the brain and their possible functions
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Review of the histamine system and the clinical effects of H<inf>1</inf> antagonists: Basis for a new model for understanding the effects of insomnia medications
2013, Sleep Medicine ReviewsCitation Excerpt :The distribution density of histamine receptor subtypes varies throughout the human brain. The highest density of H1 receptors is found in the thalamus, cerebral cortex (particularly frontal cortex), and limbic system (particularly the amygdala).9,31,32 Areas of low histamine H1 receptor density include the spinal cord and cerebellum.
Intrathecal propranolol displays long-acting spinal anesthesia with a more sensory-selective action over motor blockade in rats
2011, European Journal of PharmacologyCitation Excerpt :In radioligand binding studies, propranolol displays high affinity for β1- and β2-adrenoceptors (Fraundorfer et al., 1994; Schotte et al., 1996). It also shows moderate affinity for serotonin 5-HT1A and 5-HT1B receptors but binds with much lower, or no, affinity at 5-HT1D, 5-HT2A, 5-HT2C, 5-HT3, histamine H1, α2-adrenoceptors, and dopamine D1 and D2 receptors (Boyajian and Leslie, 1987; Engel et al., 1986; Hamon et al., 1990; Kanba and Richelson, 1984; Schlicker et al., 1989; Toll et al., 1998). It is worth studying whether these receptors are involved in propranolol spinal anesthetic effect in the next study.
Histamine and histamine receptors in pathogenesis and treatment of multiple sclerosis
2010, NeuropharmacologyCitation Excerpt :Mobilization of Ca2+ from intracellular Ca2+ stores is the main function of H1Rs. In addition, inositol phosphate accumulation further increases Ca2+ flow, subsequently Ca2+ will induce nitric oxide (NO) production, which leads to relaxation of the endothelium (Villemagne et al., 1991; Raber, 2007; Izumi et al., 1995; Li et al., 2003; Gross, 1981; Kanba and Richelson, 1984). The majority of H1Rs in the brain is located postsynaptically and is coupled positively to phospholipase C (PLC).
The physiological and pathophysiological roles of neuronal histamine: An insight from human positron emission tomography studies
2007, Pharmacology and TherapeuticsHistamine H<inf>1</inf> receptors in schizophrenic patients measured by positron emission tomography
2005, European NeuropsychopharmacologySimplified PET measurement for evaluating histamine H <inf>1</inf> receptors in human brains using [ <sup>11</sup>C]doxepin
2004, Nuclear Medicine and Biology