Evidence for the existence of serotonin type-2 receptors on cholinergic terminals in rat cortex
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Molecular imaging of serotonin degeneration in mild cognitive impairment
2017, Neurobiology of DiseaseCitation Excerpt :While both higher and lower cortical 5-HT1A receptors have been reported in MCI, lower SERT could be associated with a compensatory up-regulation of 5-HT1A receptors or with a secondary down-regulation of 5-HT1A receptors (Truchot et al., 2008; Kepe et al., 2006). The observation of lower SERT in MCI compared to controls is complementary to the results of serotonin receptor studies and suggests that lower 5-HT2A and 5-HT1A receptors may be associated, in part, with deficits in serotonergic function, as well as in other neurotransmitters associated with these receptor subtypes (e.g. acetylcholine; Quirion et al., 1985; Quirion and Richard, 1987). The limited SERT data in AD has shown lower SERT in more localized regions as compared to the present study in MCI (Ouchi et al., 2009; Marner et al., 2012).
[ <sup>11</sup>C]-DASB microPET imaging in the aged rat: Frontal and meso-thalamic increases in serotonin transporter binding
2011, Experimental GerontologyCitation Excerpt :On top of the complex interactions between the components of the 5-HT system, the regulation of the expression of 5-HT receptors cannot be regarded as independent from the actions of other neurotransmission systems. For instance, the 5-HT2A receptor has been shown to be partially associated with cholinergic nerve terminals in the cerebral cortex (Quirion et al., 1985). More research is needed to elucidate the mechanisms regulating 5-HTT expression and function, and capture the complex interplay between components of the 5-HT system and other systems of neurotransmission.
Current status of inverse agonism at serotonin<inf>2A</inf> (5-HT<inf>2A</inf>) and 5-HT<inf>2C</inf> receptors
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