Serotonin receptors in the human brain. I. Characterization and autoradiographic localization of 5-HT1A recognition sites. Apparent absence of 5-HT1B recognition sites
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Distribution of 5-HT receptors in the central nervous system: an update
2020, Handbook of Behavioral NeuroscienceCitation Excerpt :The study of its distribution in the brain also benefitted from the early development of a relatively selective ligand, 8-OH-DPAT (Middlemiss & Fozard, 1983), which soon was made available in radiolabeled form (Gozlan, el Mestikawy, Pichat, Glowinski, & Hamon, 1983). This prompted the study of its characteristics and distribution both in membrane binding and autoradiographic studies (Gozlan et al., 1988; Hoyer et al., 1985b, 1986a; Pazos, Probst, & Palacios, 1987; Pazos & Palacios, 1985). Several other radioligands in addition to [3H]-5-HT, [3H]-8-OH-DPAT have been used and/or specifically developed for the study of the brain distribution of the 5-HT1A receptor.
Cortical layers: Cyto-, myelo-, receptor- and synaptic architecture in human cortical areas
2019, NeuroImageCitation Excerpt :However, the typical six-layered pattern of cytoarchitecture cannot be found in most receptor types; consequently, the borders between receptor-dense and receptor-sparse layers do not consistently coincide with the borders of layers detectable in cyto- or myeloarchitectonic studies. Rather, receptor densities seem to show a type- and region-specific layering pattern (Amunts et al., 2010; Caspers et al., 2013, 2015; Cortés et al., 1986, 1987; Eickhoff et al., 2007, 2008; Hoyer et al., 1986a,b; Jansen et al., 1989; Morosan et al., 2005; Palomero-Gallagher et al., 2008, 2009, 2013, 2015, Pazos et al., 1987a,b; Scheperjans et al., 2005a,b; Vogt et al., 2013; Zilles et al., 2002a, 2004, 2015a; Zilles and Amunts, 2009; Zilles and Palomero-Gallagher, 2001, 2017). Since most receptors are found on dendrites and not on the cell bodies of pyramidal cells and interneurons (Kooijmans et al., 2014), and the dendrites of pyramidal cells cross many cytoarchitectonically defined layers, the layering pattern of receptors is not bound to a single layer of cell bodies (cytoarchitecture) or myelinated nerve fibers (myeloarchitecture).
Serotonin receptors nomenclature
2019, The Serotonin System: History, Neuropharmacology, and PathologyCyto- and receptor architectonic mapping of the human brain
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