Short communicationOrally administered MDMA causes a long-term depletion of serotonin in rat brain☆
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Cited by (41)
Neural and Cardiac Toxicities Associated With 3,4-Methylenedioxymethamphetamine (MDMA)
2009, International Review of NeurobiologyCitation Excerpt :It is noteworthy that MDMA is typically administered to rats via the i.p. or s.c. route whereas humans take the drug orally. Given the similar effects of MDMA in rats and humans at the same doses, it appears that drug bioavailability is comparable after i.p., s.c., or oral administration (e.g., Finnegan et al., 1988), but verification of this hypothesis awaits further investigation. Administration of MDMA at i.p. doses of 1–3 mg/kg causes marked elevations in extracellular 5-HT and DA in rat brain, as determined by in vivo microdialysis (Baumann et al., 2005; Gudelsky and Nash, 1996; Kankaanpaa et al., 1998).
Memory deficit and reduced anxiety in young adult rats given repeated intermittent MDMA treatment during the periadolescent period
2004, Pharmacology Biochemistry and BehaviorAmphetamine neurotoxicity: Accomplishments and remaining challenges
2004, Neuroscience and Biobehavioral ReviewsSynthesis, in vitro formation, and behavioural effects of glutathione regioisomers of alpha-methyldopamine with relevance to MDA and MDMA (ecstasy)
2003, Brain ResearchCitation Excerpt :The prolonged depletion occurs due to tryptophan hydroxylase inhibition [21,49] and subsequent long-term structural damage to serotonergic nerve terminals. Serotonergic neurotoxicity occurs after systemic [14,36,37,45] but not central administration of MDA or MDMA [13,30,35,38,42] in rats and non-human primates. This implies an important role for systemic metabolism in the development of neurotoxicity [42].
Methylenedioxymethamphetamine (MDMA, Ecstasy) neurotoxicity: Cellular and molecular mechanisms
2003, Brain Research Reviews
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Supported in part by CPHF subcontract No. 091A-701 to J.W. Langston, and NS 23560-01 to S.J. Peroutka.
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The authors wish to acknowledge gratefully the assistance of ZoAnn McBride and David Rosner in the preparation of this manuscript.