Autoradiographic localization of μ-opioid and neurotensin receptors within the mesolimbic dopamine system
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The effects of early life stress on motivated behaviors: A role for gonadal hormones
2020, Neuroscience and Biobehavioral ReviewsCitation Excerpt :However, estradiol can also regulate DA transmission in the NAc via the modulation of opioid function. Endogenous opioids and their receptors (μ, δ, and κ) are present throughout the mesolimbic DA system (Dilts and Kalivas, 1989; Unterwald et al., 1989; Dilts and Kalivas, 1990; Mansour et al., 1987). Activation of μ and δ opioid receptors in this circuit can increase DA release, whereas activation of κ opioid receptors reduces DA release (Chartoff et al. 2016, Spanagel et al., 1990, 1992; Ebner et al., 2010).
Bombesin-induced enhancement of memory consolidation in male and female rat pups: Role of glutamatergic and dopaminergic systems
2018, NeuropeptidesCitation Excerpt :Dopaminergic transmission in the BLA, and hippocampus is thought to be involved in consolidation of avoidance memory (Izquierdo and Medina, 1997). Activity of dopminergic system in the CNS is positively regulated by BBS-like peptides (Dilts and Kalivas, 1989; Moody and Merali, 2004b). Thus, it is likely that the dopaminergic system of these brain structures could be involved, at least in part, in the mediation of systemic BBS on memory consolidation in developing rats and await further experimentation.
Opioid-induced rewards, locomotion, and dopamine activation: A proposed model for control by mesopontine and rostromedial tegmental neurons
2017, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Mu- and delta- opioid receptors in the VTA have been localized using receptor ligand autoradiography (Kitchen et al., 1997; Mansour et al., 1987) and genetic knock-in tagging of opioid receptors with fluorescent markers (Erbs et al., 2015). Mu-opioid receptors are predominantly found on VTA GABA neurons and not on DA neurons (Dilts and Kalivas, 1989; Garzon and Pickel, 2001). Opioids directly inhibit many VTA GABA neurons that provide tonic inhibition to neighboring VTA DA neurons (Gysling and Wang, 1983; Johnson and North, 1992; Klitenick et al., 1992; Margolis et al., 2014; Matthews and German, 1984; Steffensen et al., 2006).
Glutamatergic and GABAergic susceptibility loci for heroin and cocaine addiction in subjects of African and European ancestry
2016, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :Though most drugs of abuse increase dopamine (DA) release in the striatum, the diversity of drug effects is mediated by multiple neurotransmitters (Di Chiara et al., 2004). Opioids indirectly disinhibit DA neurons by inhibition of gamma-aminobutyric acid (GABA) release through binding opioid receptors on GABA interneurons in the ventral tegmental area (VTA) (Dilts and Kalivas, 1989; Johnson and North, 1992). Cocaine increases DA availability in the striatum through the blockade of transporter-mediated reuptake.
Modulation of neuropeptide FF (NPFF) receptors influences the expression of amphetamine-induced conditioned place preference and amphetamine withdrawal anxiety-like behavior in rats
2012, PeptidesCitation Excerpt :In the VTA, NPFF receptors are localized on dopaminergic and GABAregic neurons [94]. Opioid receptors in the VTA are also located on GABAergic interneurons [14,59]. Disinhibition of GABAergic neurons in VTA by opiates may produce an increase of the neuronal activity of dopamine mesocorticolimbic pathway.