Elsevier

Brain Research

Volume 493, Issue 2, 31 July 1989, Pages 391-397
Brain Research

Induction of c-fos-like protein within the lumbar spinal cord and thalamus of the rat following peripheral stimulation

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Abstract

Noxious stimulation induces c-fos-like protein within neurons of the spinal cord and thalamus in patterns that suggest c-fos induction may serve as a marker for activity within nociresponsive pathways. Similar patterns of immunoreactivity were not seen following gentle mechanical stimulation or in control animals. Within the thalamus, noxious stimulation induces immunoreactivity not only in traditionally expected locations, but also within the paraventricular, submedial and reuniens nuclei.

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    This work was supported by Research Grants 5K08NS01006 and 5P0INS14899 from the National Institutes of Neurologic and Communicative Disorders and Stroke of the United States Public Health Service.

    §

    I am grateful to Dr. Alan Light, who first alerted me to the possibilities of c-

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