Elsevier

Brain Research

Volume 515, Issues 1–2, 7 May 1990, Pages 303-308
Brain Research

The identification of a brainstem site controlling spinal sexual reflexes in male rats

https://doi.org/10.1016/0006-8993(90)90611-EGet rights and content

Abstract

It has long been assumed that the brainstem exerts a tonic descending inhibitory influence on spinal sexual reflexes, but the source of this inhibition is unknown. Sexual responses (penile erection and ejaculatory movements) were elicited in anesthetized male rats using urethral stimuli. Using brainstem transections and electrolytic and neurotoxic lesions, we have identified a group of neurons in the paragigantocellular reticular nucleus in the ventral medulla which mediates this descending inhibition. Correlative neuroanatomical studies indicate that the inhibition is mediated via a direct projection to pelvic efferent neurons and interneurons. These results promise new approaches to the treatment of human sexual disorders.

Reference (56)

  • LoewyA.D.

    Descending pathways to the sympathetic preganglionic neurons

  • RoseJ.D.

    Pontine unit responses to genital stimulation in estrous and anestrous cats

    Brain Research

    (1973)
  • RoseJ.D.

    Response properties and anatomical organization of pontine and medullary units responsive to vaginal stimulation in the cat

    Brain Research

    (1975)
  • RoseJ.D. et al.

    Responses of single units in the medulla to genital stimulation in estrous and anestrous cats

    Brain Research

    (1973)
  • RossC.A. et al.

    Projections to the spinal cord from neurons close to the ventral surface of the hindbrain in the cat

    Neurosci. Lett.

    (1981)
  • SachsB.D. et al.

    Spinal pacemaker controlling sexual reflexes in male rats

    Brain Research

    (1979)
  • AndrezikJ.A. et al.

    Reticular formation, central gray and related tegmental nuclei

  • AndrezikJ.A. et al.

    The nucleus paragigantocellularis lateralis in the rat. Conformation and cytology

    Anat. Embryol.

    (1981)
  • AndrezikJ.A. et al.

    The nucleus paragigantocelularis lateralis in the rat. Demonstration of afferents by the retrograde transport of horseradish peroxidase

    Anat. Embryol.

    (1981)
  • Aston-JonesG. et al.

    Lumbar cord densely innervates a specific subregion of the periaqueductal gray which projects to paragigantocellularis and prepositus hypoglossi, the the major afferents to locus coeruleus (LC): possible connections between the periphery and LC

    Soc. Neurosci. Abstr.

    (1987)
  • BarfieldR.J. et al.

    Sexual behavior: extreme reduction of postejaculatory refractory period by midbrain lesions in male rats

    Science

    (1975)
  • BeachF.A.

    Cerebral and hormonal control of reflexive mechanism involved in copulatory behavior

    Physiol. Rev.

    (1967)
  • BeckettS.D. et al.

    Blood pressures and peniile muscle activity in stallion during coitus

    Am. J. Physiol.

    (1973)
  • BeckettS.D. et al.

    Corpuz cavernosum penis pressure and penile muscle activity in the bull during coitus

    Am. J. Vet. Res.

    (1974)
  • BeckettS.D. et al.

    The corpus spongiosum penis pressure and external penile muscle activity in the goat during coitus

    Biol. Reprod.

    (1975)
  • BergmanB. et al.

    The effect on erection and orgasm of cystomy, prostatectomy and vesiculectomy for cancer of the bladder: a clinical and electromyographic study

    Br. J. Urol.

    (1979)
  • BorsE. et al.

    Neurological disturbances of sexual function with special reference to 529 patients with spinal cord injury

    Urol. Surv.

    (1960)
  • BreedloveS.M. et al.

    Hormone accumulation in a sexually dimorphic motor nucleus of the rat spinal cord

    Science

    (1980)
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