Elsevier

Brain Research

Volume 510, Issue 2, 5 March 1990, Pages 335-338
Brain Research

Protective effect of α-tocopherol on ischemic neuronal damage in the gerbil hippocampus

https://doi.org/10.1016/0006-8993(90)91386-UGet rights and content

Abstract

The effect of α-tocopherol (vitamin E) on ischemic neuronal damage was studied in the gerbil. The animals were subjected to 5 min of cerebral ichemia by bilateral common carotid artery occlusion. Immediately after ischemia, α-tocopherol at a dose of 50 or 100 mg/kg was administered intravenously. Morphological changes in the CA1 sector of the hippocampus were evaluated after 7 days of survival. α-Tocopherol prevented ischemia-induced neuronal death. The average density of CA1 pyramidal neurons (cells/mm, mean ± S.E.M.) was 252 ± 8 (n = 8) in the sham-operated group, 50 ± 20 (n = 8) in the ischemia group, and 140 ± 35n = 8) and 182 ± 36 (n = 8) in the groups treated with α-tocopherol at the doses of 50 and 100 mg/kg, respectively. The results suggest that free radical scavenging action of α-tocopherol played an important role in preventing the neuronal death.

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