Activation of 5-HT3 receptor by 1-phenylbiguanide increases dopamine release in the rat nucleus accumbens

doi:10.1016/0006-8993(91)90050-6

Brain Research

Volume 543, Issue 2, 15 March 1991, Pages 354-357

https://doi.org/10.1016/0006-8993(91)90050-6 Get rights and content

Abstract

The serotonin-3 (5-HT₃) agonist 1-phenylbuguanide (0.1–1.0 mM in perfusate) caused a robust, dose-dependent enhancement of extracellular dopamine content in nucleus accumbens as measured by in vivo microdialysis. This action was antagonized by co-perfusion of the 5-HT₃ antagonists zacopride and GR38032F (1 mM in perfusate). Similar effects were observed in 5-HT-denervated rats. These findings suggest that there is a potent modulation of dopamine (DA) release in the nucleus accumbens mediated via 5-HT₃ receptors, which appear to be located presynaptically on DA terminals of the mesolimbic DA pathway.

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: Supported by a research grant from the Aaron Diamond Foundation to E.L.G. We thank Dr. A.M. Etgen for helpul comments.

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Activation of 5-HT3 receptor by 1-phenylbiguanide increases dopamine release in the rat nucleus accumbens

Abstract

Eur. J. Pharmacol.

Eur. J. Pharmacol.

Neuroscience

Life Sci.

Neuropharmacology

Eur. J. Pharmacol.

Neuroscience

Trends Physiol. Sci.

Neurosci. Lett.

[3H]Zacopride: ligand for the identification of 5-HT3 recognition sites

J. Pharm. Pharmacol.

Activation of 5-HT₃ receptor by 1-phenylbiguanide increases dopamine release in the rat nucleus accumbens

[³H]Zacopride: ligand for the identification of 5-HT₃ recognition sites