Action site of circulating interleukin-1 on the rabbit brain
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Neural circuits mediating circulating interleukin-1β-evoked fever in the absence of prostaglandin E2 production
2022, Brain, Behavior, and ImmunityCitation Excerpt :IL-1β can indirectly influence neuronal activity by inducing endothelial cells in the brain to produce and release cytokines, prostaglandins, and other mediators (Schiltz and Sawchenko, 2002, Konsman et al., 2004). Additionally, cytokines can diffuse from the circulation to circumventricular organs, where they can act to modulate the activity of brain cells (Hashimoto et al., 1991, Broadwell and Sofroniew, 1993, Maness et al., 1998, Quan et al., 1998, Vitkovic et al., 2000), since IL-1 receptors are found within the central nervous system (Ericsson et al., 1995). Alternatively, IL-1 changes blood–brain-barrier (BBB) permeability (Blamire et al., 2000, Skinner et al., 2009) and can be transported from the blood to the brain via the BBB (Banks et al., 1991, Banks et al., 1993, McLay et al., 2000, Argaw et al., 2006, Erickson et al., 2018).
Neuroinflammation in hepatic encephalopathy: Mechanistic aspects
2015, Journal of Clinical and Experimental HepatologySingle episode of mild murine malaria induces neuroinflammation, alters microglial profile, impairs adult neurogenesis, and causes deficits in social and anxiety-like behavior
2014, Brain, Behavior, and ImmunityCitation Excerpt :Peripheral proinflammatory cytokines like TNF-α, IL-1β, and IL-1α have blood to brain saturable transport systems (Banks et al., 1989; Gutierrez et al., 1993; Erickson et al., 2011), and can induce neurotoxicity and initiate a neuroinflammatory cascade (Qin et al., 2007). The proinflammatory cytokines diffuse into the brain (Hashimoto et al., 1991; Broadwell and Sofroniew, 1993) to induce an innate immune response, mediated primarily by microglia (Lampron et al., 2013). Circulating IP-10 and C5a have been shown to have a role in the recruitment of inflammatory leukocytes to brain blood vessels in cerebral malaria (Nie et al., 2009; Patel et al., 2008).
Effective induction of protective systemic immunity with nasally administered vaccines adjuvanted with IL-1
2010, VaccineCitation Excerpt :We tested IL-1β in rabbits at doses of 0.5, 12.5, 312.5 and 7812.5 ng/kg (0.0005–7.8 μg/kg) to provide an extensive range of IL-1 doses to allow us to effectively evaluate the pyrogenicity of IL-1β when delivered nasally and to use an IL-1 dose greater than that used in human studies when delivered parenterally to determine if a higher IL-1β dose could be used nasally as a vaccine adjuvant without exhibiting pyrogenic effects. The doses of IL-1β we evaluated in rabbits were comparable to those used by others to evaluate the pyrogenic activity of IL-1β in rabbits [90]. Others have reported that 100 μg of recombinant ovine IL-1β provided both adjuvant and pyrogenic activity when delivered parenterally to sheep [79].
Psychoneuroimmunology of Stroke
2009, Immunology and Allergy Clinics of North AmericaCitation Excerpt :The brain now is recognized as immunologically active and is in direct contact with the immune system; thus a systemic inflammatory response can influence brain function. Cytokines play a local role at the point of infection in mediating immune defense in response to a pathogenic challenge, but they also signal the CNS, thereby initiating brain-mediated defenses such as fever.126 Although it is clear that systemic cytokines such as IL-1 signal the brain, the exact mechanisms by which this signaling is accomplished remain unclear.