The AT2 angiotensin receptor subtype predominates in the 18 day gestation fetal rat brain
Reference (21)
- et al.
Two angiotensin II binding sites in rat brain revealed using [125I]Sar1, Ile-8-angiotensin II and selective nonpeptide antagonists
Biochem. Biophys. Res. Commun.
(1990) - et al.
Identification of angiotensin II receptor subtypes
Biochem. Biophys. Res. Commun.
(1989) - et al.
Non-peptide angiotensin II receptor antagonists discriminate subtypes of125I-angiotensin II binding sites in the rat brain
Eur. J. Pharmacol.
(1990) - et al.
Characterization of angiotensin II receptors in the rat fetus
Peptides
(1989) - et al.
Angiotensin II induces expression of the c-fos gene through protein kinase C activation and calcium ion mobilization in cultured vascular smooth muscle cells
Biochem. Biophys. Res. Commun.
(1988) Oncogenes and growth control
Cell
(1987)- et al.
Angiotensin II receptor subtypes in the rat brain
Eur. J. Pharmacol.
(1990) - et al.
Discrimination of angiotensin II receptor subtype distribution in the rat brain using non-peptidic receptor antagonists
Regul. Pept.
(1991) - et al.
Sulfhydryl reducing agents distinguish two subtypes of angiotensin II receptors in the rat brain
Brain Research
(1991) - et al.
Angiotensin II induces c-fos mRNA in aortic smooth muscle. Role of Ca2+ mobilization and protein kinase C activation
J. Biol. Chem.
(1989)
Cited by (43)
AT2 receptor signaling and sympathetic regulation
2011, Current Opinion in PharmacologyCitation Excerpt :The prevailing dogma is that the AT2R subtype in the brain is predominant in the fetus, while the AT1R subtype is predominant in adults. This is based primarily on studies using autoradiography [20,21•], quantitative autoradiography [22], and in situ hybridization [23] techniques. Unfortunately, there are no data at the protein level to confirm or refute this idea.
The renin-angiotensin system in retinal health and disease: Its influence on neurons, glia and the vasculature
2010, Progress in Retinal and Eye ResearchCitation Excerpt :The actions of the AT2R are not completely understood, but may oppose some actions of AT1Rs (Chung et al., 1998). AT2Rs are abundantly expressed in foetal and developing tissues and then recede after birth (Alcorn et al., 1996; Cook et al., 1991; Grady et al., 1991). This phenomenon has been interpreted to reflect the potential involvement of AT2Rs in neuronal differentiation and plasticity (Millan et al., 1991).
Development of AT<inf>1</inf> and AT<inf>2</inf> receptors in the ovine fetal brain
2004, Developmental Brain Research