Elsevier

Brain Research

Volume 560, Issues 1–2, 27 September 1991, Pages 334-336
Brain Research

The AT2 angiotensin receptor subtype predominates in the 18 day gestation fetal rat brain

https://doi.org/10.1016/0006-8993(91)91254-XGet rights and content

Abstract

The angiotensin II receptor subtype-specific antagonists Dup 753 (AT1) and PD 123177 (AT2) were used to characterize the angiotensin II receptor subtypes present in 18 day gestation fetal Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rat brain using in vitro receptor autoradiography. The AT2 subtype was predominant in the brain of both rat strains, even in areas that display predominantly the AT1 subtype in the adult rat brain.

Cited by (43)

  • AT2 receptor signaling and sympathetic regulation

    2011, Current Opinion in Pharmacology
    Citation Excerpt :

    The prevailing dogma is that the AT2R subtype in the brain is predominant in the fetus, while the AT1R subtype is predominant in adults. This is based primarily on studies using autoradiography [20,21•], quantitative autoradiography [22], and in situ hybridization [23] techniques. Unfortunately, there are no data at the protein level to confirm or refute this idea.

  • The renin-angiotensin system in retinal health and disease: Its influence on neurons, glia and the vasculature

    2010, Progress in Retinal and Eye Research
    Citation Excerpt :

    The actions of the AT2R are not completely understood, but may oppose some actions of AT1Rs (Chung et al., 1998). AT2Rs are abundantly expressed in foetal and developing tissues and then recede after birth (Alcorn et al., 1996; Cook et al., 1991; Grady et al., 1991). This phenomenon has been interpreted to reflect the potential involvement of AT2Rs in neuronal differentiation and plasticity (Millan et al., 1991).

View all citing articles on Scopus
View full text