Chronicl-DOPA treatment in the unilateral 6-OHDA rat: evidence for behavioral sensitization and biochemical tolerance
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Cited by (84)
The preferential nNOS inhibitor 7-nitroindazole and the non-selective one N<sup>G</sup>-nitro-l-arginine methyl ester administered alone or jointly with l-DOPA differentially affect motor behavior and monoamine metabolism in sham-operated and 6-OHDA-lesioned rats
2015, Brain ResearchCitation Excerpt :Assuming the hypofunction of the nitrergic system in 6-OHDA-lesioned rats, in our recently published study we have demonstrated that chronic combined administration of a low dose of the NO donor molsidomine (2 mg/kg) jointly with the widely used antiparkinsonian drug L-3,4-dihydroxyphenylalanine (l-DOPA; 25 mg/kg) caused a slight but significant decrease in the number of contralateral rotations and a marked enhancement in a tissue concentrations of l-DOPA-derived DA in the STR and SN when compared to the values of these parameters in rats treated chronically with l-DOPA alone (Lorenc-Koci et al., 2013). The rotational behavior after l-DOPA is commonly used as an indicator of antiparkinsonian function of potential novel drugs but also it is considered to be a measure of dyskinesiogenic liability (Carey, 1991; Henry et al., 1998; Lane et al., 2006). In our study rotational behavior after l-DOPA was slightly reduced in the presence of molsidomine, therefore the obtained result could be interpreted as a modulation of dopaminergic response but also as a potential antidyskinetic effect (Lorenc-Koci et al., 2013).
Intranasal delivery of dopamine to the striatum using glycol chitosan/sulfobutylether-β-cyclodextrin based nanoparticles
2015, European Journal of Pharmaceutics and BiopharmaceuticsChronic l-DOPA treatment attenuates behavioral and biochemical deficits induced by unilateral lactacystin administration into the rat substantia nigra
2014, Behavioural Brain ResearchCitation Excerpt :The number of rotations increased with elapsing time and reached a plateau after one-week treatment. These results are in accordance with well-documented findings that repeated l-DOPA treatment is accompanied by a marked enhancement in rotational response [30,31,33,36,49]. A single “priming” administration of apomorphine which we used to determine the extent of lesion one week before the first dose of l-DOPA could further enhance the rotational response elicited by l-DOPA by induction of sensitization phenomenon.
Abnormal involuntary movement (AIM) expression following D2 dopamine agonist challenge is determined by the nature of prior dopamine receptor stimulation (priming) in 6-hydroxydopamine lesioned rats
2013, Pharmacology Biochemistry and BehaviorCitation Excerpt :Since its development several decades ago, the 6-hydroxydopamine (6-OHDA) rat model of PD has served as a valuable means to explore the consequences of dopamine depletion on motor behavior (Ungerstedt and Arbuthnott, 1970). In this model, rats receive a unilateral stereotaxic injection with the neurotoxin 6-OHDA to selectively destroy dopaminergic neurons, resulting in dopamine agonist-mediated motor behavior, in which the animals rotate contralateral to the dopamine-denervated striatum (Carey, 1991). Numerous studies have demonstrated that 6-OHDA rats treated with D1, D2, or D1/D2 dopamine agonists display a behavioral sensitization phenomenon known as “priming” or “reverse tolerance” such that repeated administration of the same dose of dopamine agonist produces contralateral rotational behavior of increasing magnitude (Asin et al., 1995; Carey, 1991; Gancher and Mayer, 1995; Paul et al., 1995; Pinheiro-Carrera et al., 1994; Pollack et al., 1997; Rouillard et al., 1987).
The dopaminergic stabilizer pridopidine decreases expression of l-DOPA-induced locomotor sensitisation in the rat unilateral 6-OHDA model
2013, European Journal of Pharmacology