Research reportOpiate infusion into nucleus accumbens: contrasting effects on motor activity and responding for conditioned reward
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Cited by (88)
Shifting motivational states: The effects of nucleus accumbens dopamine and opioid receptor activation on a modified effort-based choice task
2021, Behavioural Brain ResearchCitation Excerpt :However, it is less clear whether similar treatments increase the incentive properties of food-associated cues, as has been shown with dopamine receptor agonists [e.g., 54]. Reports using conditioned reinforcement paradigms have yielded conflicting results, with NAc μ-opioid receptor stimulation causing enhancement of lever pressing for food-reinforced cues in one report [55], but not in another [56]. Pavlovian-instrumental transfer is enhanced by NAc injections of DAMGO [57], which supports a potential role for μ-opioid receptors in driving incentive motivation toward Pavlovian cues.
Mu-opioid receptor activation in the medial shell of nucleus accumbens promotes alcohol consumption, self-administration and cue-induced reinstatement
2016, NeuropharmacologyCitation Excerpt :Additionally, NAc DAMGO increased lever pressing for alcohol-paired cues in a cue-induced reinstatement test, suggesting that DAMGO potentiates the reinforcing properties of conditioned incentive cues. Previous studies with food reward have reported no increase in conditioned reinforcement by NAc DAMGO in a classic conditioned reinforcement paradigm (Cunningham and Kelley, 1992) and a decrease in “cue-induced” reinstatement (Guy et al., 2011). These results may be due to a combination of the biphasic nature of DAMGO effects in NAc and the relatively brief nature of the tests in these cases (45 and 20 min, respectively).
Mapping brain circuits of reward and motivation: In the footsteps of Ann Kelley
2013, Neuroscience and Biobehavioral ReviewsCitation Excerpt :For example, microinjections of amphetamine or DAMGO into NAc shell or core produces robust increases in cue-triggered ‘wanting’ for sugary rewards as measured in Pavlovian to instrumental transfer (PIT) or in neuronal incentive salience signals (Pecina and Berridge, 2008; Wyvell and Berridge, 2000). Similarly, microinjections of DAMGO or amphetamine raise conditioned reinforcement value or breakpoint values in instrumental tests that might reflect incentive salience (Cunningham and Kelley, 1992; Kelley and Delfs, 1991; Zhang et al., 2003). We have found that DAMGO microinjections in other striatal-type structures such as the central amygdala also increase cue-triggered ‘wanting’ in PIT and likewise increase the motivational magnet strength of an individual's favorite reward cue in a sign-tracking versus goal-tracking test (autoshaping) (DiFeliceantonio and Berridge, 2012; Mahler and Berridge, 2009, 2012).
Nucleus accumbens dopamine and mu-opioid receptors modulate the reinstatement of food-seeking behavior by food-associated cues
2011, Behavioural Brain ResearchCitation Excerpt :While stimulation of mu-opioid receptors of the NAcc does increase the effort that rats will expend to obtain sucrose reinforcement [43], this is not the first report that has failed to show enhanced responding to reward-associated cues following NAcc mu-opioid stimulation in the absence of primary food reinforcement. Previously, Cunningham and Kelley [44] reported no effects of NAcc opiate receptor activation on lever responding in a conditioned reinforcement paradigm. Likewise, the current experiments do not support a role for ventral striatum mu-opioid receptors in enhancing the incentive value of reward-predictive cues.