Elsevier

Brain Research

Volume 624, Issues 1–2, 8 October 1993, Pages 339-341
Brain Research

Vasoactive intestinal peptide: a growth promotor in neuroblastoma cells

https://doi.org/10.1016/0006-8993(93)90100-2Get rights and content

Abstract

Vasoactive intestinal peptide (VIP) is a neuromodulator, growth regulator and secretagogue for neuronal survival factors. Moreover, VIP has been suggested to be a mitogenic factor for embryonic neurons in the sympathetic nervous system. We now show that VIP had mitogenic activity in a human neuroblastoma cell line (NMB), as measured by cell number and thymidine incorporation. This mitogenic activity was dose dependent and was decreased with culture maturation. Northern blot analysis revealed VIP mRNA transcripts in this cell line suggesting an autocrine role for VIP in neurogenesis.

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Supported by the Israel Cancer Association. VIP was synthesized and labeled by S. Rubinrout and her help is gratefully acknowledged.

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