Elsevier

Brain Research

Volume 629, Issue 1, 26 November 1993, Pages 146-148
Brain Research

The effect of central blockade of kappa-opioid receptors on neuropeptide Y-induced feeding in the rat

https://doi.org/10.1016/0006-8993(93)90493-7Get rights and content

Abstract

Neuropeptide Y (NPY) and the endogenousK-opioid receptor ligand, dynorphin (dyn), stimulate feeding when injected centrally in the rat. Norbinaltorphimine (norBNI, 25 nmol) reduced the feeding response to NPY (2.4 nmol) by 67% (P < 0.02). An additive effect of dynorphin and NPY was seen on food intake (saline0.8 ± 0.1,dyn1.9 ± 0.4,and the NPY9.7 ± 2.2). A component of NPY-induced feeding maycor* be mediated byK-opioid neuronal systems.

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