Elsevier

Brain Research

Volume 613, Issue 2, 11 June 1993, Pages 347-351
Brain Research

Adenosine receptor antagonists potentiate dopamine receptor agonist-induced rotational behavior in 6-hydroxydopamine-lesioned rats

https://doi.org/10.1016/0006-8993(93)90925-DGet rights and content
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Abstract

Adenosine receptor antagonists, DMPX, PACPX and theophylline, produce contralateral rotations in unilateral 6-hydroxydopamine-lesioned rats. DMPX and theophylline markedly increase rotations produced by bromocriptine (a dopamine D2 receptor agonist) and/or SKF38393A (a dopamine D1 receptor agonist). All of these effects are inhibited by CGS21680C (an adenosine A2 receptor agonist). These findings suggest synergistic interactions among D1, D2 and A2 receptors that may be relevant to the treatment of Parkinson's disease.

Keywords

Adenosine
Dopamine
Parkinson's disease
Rotational behavior
6-Hydroxydopamine

Cited by (0)

This work was supported by the Parkinson's Disease Foundation (New York, USA).

1

We would like to thank Dr. S. Fahn for his advice and support. We would also like to thank Dr. R.A. Lovell from Ciba-Geigy, who supplied the CGS21680C and CGS15943A used in these studies.