Elsevier

Brain Research

Volume 669, Issue 1, 9 January 1995, Pages 79-85
Brain Research

Involvement of ryanodine receptors in sphingosylphosphorylcholine-induced calcium release from brain microsomes

https://doi.org/10.1016/0006-8993(94)01234-9Get rights and content

Abstract

Sphingosylphosphorylcholine (SPC) releases Ca2+ from brain microsomes. SPC-induced Ca2+ release differs from IP3-induced Ca2+ release in that it is more extensive in the cerebrum than in the cerebellum. SPC has little effect on [3H] IP3 binding but enhances [3H] ryanodine binding, as expected for an activator or ryanodine receptors. SPC-induced Ca2+ release is inhibited by ryanodine receptor blockers but not by selective blockers of IP3 receptors. We conclude that SPC releases Ca2+ from brain microsomes by activating ryanodine receptors rather than IP3 receptors. Activation of an additional SPC-sensitive pathway for releasing Ca2+ is not precluded.

Reference (33)

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