Requirement of basolateral amygdala neuron activity for the induction of long-term potentiation in the dentate gyrus in vivo
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Cited by (80)
Amygdala-hippocampal interactions in synaptic plasticity and memory formation
2021, Neurobiology of Learning and MemoryMemory Modulation
2017, Learning and Memory: A Comprehensive ReferenceActivation of beta- and alpha-2-adrenoceptors in the basolateral amygdala has opposing effects on hippocampal-prefrontal long-term potentiation
2017, Neurobiology of Learning and MemoryCitation Excerpt :Generally, post-learning treatments thought to reduce excitability of the BLA reduced memory retention, while post-learning treatments thought to increase excitability of the BLA improved memory retention (for review see Pare, 2003). Importantly, while our current results and the previous publication by Richter-Levin and Maroun (2010) both indicate that activation of the BLA impairs H-PFC LTP, other studies indicate that activation of the BLA facilitates LTP in the dentate gyrus (Akirav & Richter-Levin, 1999; Frey, Bergado-Rosado, Seidenbecher, Pape, & Frey, 2001; Ikegaya, Saito, & Abe, 1995a, 1995b, 1996; Li & Richter-Levin, 2013). It would therefore be predicted that BLA activation and inhibition would have opposite effects on specifically hippocampal-dependent and H-PFC-dependent learning.
Amygdala electrical stimulation inducing spatial memory recovery produces an increase of hippocampal bdnf and arc gene expression
2016, Brain Research BulletinCitation Excerpt :In addition to its well-known role in the mediation of emotions, the amygdala, particularly its basolateral division (BLA), has been critically implied in the emotional potentiation of memory by facilitating information processing and storage in other structures, like the hippocampus (Akirav et al., 2001; McGaugh, 2004; Roozendaal et al., 2009). Moreover, animal studies have also shown that acute electrical stimulation of the BLA is able to regulate neural plasticity in the dentate gyrus through memory related mechanisms (LTP, Long-term potentiation) contributing in this way to the memory consolidation (Kim et al., 2001, 2005; Nakao et al., 2004; Frey et al., 2001; Ikegaya et al., 1995; Ikegaya et al., 1996). The amygdala sends both direct and indirect projections to the hippocampus via the enthorinal cortex and subcortical structures like the medial septum (Bergado et al., 2007).
How the amygdala affects emotional memory by altering brain network properties
2014, Neurobiology of Learning and MemoryCitation Excerpt :Electrical stimulation of the BLA enhances the induction of long-term potentiation (LTP) in the dentate gyrus of the hippocampus (Akirav & Richter-Levin, 1999; Almaguer-Melian, Martínez-Martí, Frey, & Bergado, 2003; Frey, Bergado-Rosado, Seidenbecher, Pape, & Frey, 2001; Ikegaya, Saito, & Abe, 1995; Vouimba & Richter-Levin, 2013), but appear to block LTP in the CA1 region of the hippocampus (Vouimba & Richter-Levin, 2005, 2013). Also, selective lesions of the BLA or infusions of a ß-adrenoceptor antagonist into the BLA block the induction of LTP in the dentate gyrus (Ikegaya et al., 1995; Ikegaya, Nakanishi, Saito, & Abe, 1997; Ikegaya, Saito, & Abe, 1994). Norepinephrine and glucocorticoids both influence the effects of BLA stimulation on dentate gyrus LTP (Akirav & Richter-Levin, 2002; Vouimba, Yaniv, & Richter-Levin, 2007).