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Rabbits can be conditioned in a food-induced place preference paradigm
2022, Brain ResearchCitation Excerpt :In our study, subjects of the Reward, but not of the Ad libitum and No Reward groups, spent longer time, showed a higher preference score, and significantly increased the rearing behavior in the reinforced compartment during the Test session, when food was no longer available. In the present study, the subjects were in caloric restriction, which has been previously used in CPP protocols in combination with drugs (Carr and Papadouka, 1994) and food (Figlewicz et al. 2001; Maes and Vossen 1993; Spyraki et al., 1982). It has been demonstrated that hunger per se is not a conditioning factor in CPP (Maes and Vossen, 1993; Cravens and Renner, 1970; Mineka, 1975; Weingarten, 1985).
Reward deficits in compulsive eating
2019, Compulsive Eating Behavior and Food Addiction: Emerging Pathological ConstructsAppetite and reward
2010, Frontiers in NeuroendocrinologyCitation Excerpt :In the same study these authors show that ICV injection of the non-selective opioid antagonist, naltrexone, reverses the potentiation of BSR by food restriction at perifornical sites [62]. The modulation of BSR by weight loss has been replicated several times [4,5,57,59,108–111], and depends on the site of stimulation in the LH [112]. These data suggest that stimulation of the LH recruits at least two anatomically and functionally distinct subpopulations of rewards neurons, one of which is linked to the regulation of body weight and can be activated by stimulating neurons residing in or coursing through the perifornical LH.
Treatment of anorexia nervosa: Insights and obstacles
2008, Physiology and BehaviorCitation Excerpt :In animal models various aspects of the characteristic behaviors expressed in anorexia nervosa have been associated with neural changes that may facilitate the maintenance of the disorder. For example, food restriction increases the rewarding effects of food and of drugs of abuse [18,19] and chronic exercise is associated with decreased mu-opioid sensitivity in female rats [20], suggesting that a disturbance in opioidergic activity could contribute to the escalating patterns of self-starvation and excessive exercise observed in anorexia nervosa. Physiological consequences of starvation, including delayed gastric emptying and prolonged gastric transit times, also sustain restrictive eating patterns as they result in early satiety and chronic constipation [21,22].