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Neural circuit mechanisms of the cholecystokinin (CCK) neuropeptide system in addiction
2022, Addiction NeuroscienceMedications development for food-based and drug use disorders
2019, Advances in PharmacologyCitation Excerpt :These last findings are especially promising and deserve in-depth follow-up. Of note, CCK antagonists have been found to be without effect in opioid self-administration studies (Higgins, Joharchi, Wang, Corrigall, & Sellers, 1994), suggesting that their potential value as candidate medications for substance use disorder may be restricted to psychomotor stimulants like cocaine. Cocaine- and amphetamine-regulated transcript (CART) is a neuropeptide that is regulated by several gut peptides including leptin (Kristensen et al., 1998; Lee et al., 2013), ghrelin (de Lartigue, Dimaline, Varro, & Dockray, 2007), and CCK (Broberger, Holmberg, Kuhar, & Hökfelt, 1999; de Lartigue et al., 2007; Maletínská et al., 2008; for review, see Lau & Herzog, 2014).
A novel synthesis of pyrrolo[1,2-d][1,4]diazocines from tetrahydropyrrolo[1,2-a] pyrazines using activated alkynes in pyrazine ring expansion
2010, TetrahedronCitation Excerpt :In many cases their structures strongly resemble the whole composition of low-membered analogues in accordance to the fundamental bioisosteric rules.3 The few pathways towards benzoannulated pyrrolodiazocines include Ugi-type reaction and Dieckman condensation4 of adequately substituted pyrroles and a multi-step synthesis of fully hydrogenated pyrrolo[1,2-a][1,4]diazocines and pyrrolo[1,2-a][1,5]diazocines starting from proline and pyroglutamic acid.5 It was shown that pyrrolo[1,2-a][1,4]diazocines could be used as dipeptide reverse-turn mimetics6 exhibiting cognition enhancing activity.
Effects of central neurokinin-1 receptor antagonism on cocaine- and opiate-induced locomotor activity and self-administration behaviour in rats
2006, Pharmacology Biochemistry and BehaviorBrain substrates for increased drug seeking during protracted withdrawal
2004, Neuropharmacology
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Present address: The Glaxo Unit of Behavioural Psychopharmacology, Division of Biosciences, University of Hertfordshire, College Lane, Hatfield, Herts. AL10 9AB, UK