Occurrence of the opiate alkaloid-selective μ3 receptor in mammalian microglia, astrocytes and Kupffer cells
Reference (52)
- et al.
Induction of tryptophan oxygenase in primary rat liver cell suspensions by glucocorticoid hormone
Exp. Cell Res.
(1972) - et al.
Presence in neuroblastoma cells of a μ3 receptor with selectivity for opiate alkaloids but without affinity for opioid peptides
Brain Res.
(1994) Regional heterogeneity among astrocytes in the central nervous system
Neurochem. Int.
(1990)- et al.
Characterization of opioid-dependent glial development in dissociated and organotypic cultures of mouse central nervous system
Dev. Brain Res.
(1991) - et al.
Receptors for neurotransmitters on astrocytes in the mammalian central nervous system
Prog. Neurobiol.
(1993) - et al.
Glial and neuronal opioid receptors: apparent positive cooperativity observed in intact cultured cells
Brain Res.
(1988) Morphine receptors in immunocytes and neurons
Adv. Neuroimmunol.
(1994)- et al.
Murine macrophage cell lines contain μ3 opiate receptors
Eur. J. Pharmacol.
(1995) - et al.
Enhanced binding of morphine and nalorphine to opioid delta receptor by glucuronate and sulfate conjugation at the 6-position
Life Sci.
(1987) - et al.
Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain
Neuroscience
(1985)
Macrophages and the nervous system
Intl. Rev. Cytol.
Morphine amplifies HIV-1 expression in chronically infected promonocytes cocultured with human brain cells
J. Neuroimmunol.
Cell-type specific markers for distinguishing and studying neurons and the major classes of glial cells in culture
Brain Res.
Microglia and microglia-derived brain macrophages in culture: generation from axotomized rat facial nuclei, identification and characterization in vitro
Brain Res.
The immuneneuro-link and the macrophage: postcardiotomy delirium, HIV-associated dementia and psychiatry
Prog. Neurobiol.
Endogenous morphine and related opiates, a new class of chemical messengers
Adv. Neuroimmunol.
Desipramine modulation of σ and opioid peptide receptor expression in glial cells
Peptides
Evidence for the implication of phosphoinositol signal transduction in μ-opioid inhibition of DNA synthesis
J. Neurochem.
A monoclonal anti-idiotypic antibody to opioid receptors labels desipramine-induced opioid binding sites on rat C6 glioma cells and attenuates thymidine incorporation into DNA
Glia
κ-Opioid agonist modulation of [3H]thymidine incorporation into DNA: evidence for the involvement of pertussis toxin-sensitive G-protein coupled phosphoinositide turnover
J. Neurochem.
Priming effect of morphine on the production of tumor necrosis factor-α by microglia: implications in respiratory burst activity and human immunodeficiency virus-1 expression
J. Pharmacol. Exp. Ther.
Direct coupling of opioid receptors to both stimulatory and inhibitory guanine nucleotide-binding proteins in F-11 neuroblastoma-sensory neuron hybrid cells
Cerebral cortex cultures from postnatal GM2 gangliosidosis cats
Soc. Neurosci. Abstr.
Morphine-6-glucoronide is more mu-selective and potent in analgesic tests than morphine
Prog. Clin. Biol. Res.
Morphine and its psychiatric implications
Adv. Neuroimmunol.
Bone marrow origin of hepatic macrophages (Kupffer cells) in humans
Science
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2021, International Review of NeurobiologyCitation Excerpt :The opioid-induced activation of glial cells could be mediated by binding at various opioid receptors expressed by glial cells. Previous work has shown that all four members of opioid receptors (μ, δ, κ and nociceptin receptors) are expressed by glial cells (Chao, Gekker, Hu, et al., 1996; Dobrenis, Makman, & Stefano, 1995; Eriksson, Hansson, & Rönnbäck, 1992; Fu, Zhu, Wang, & Wu, 2007; Gurwell, Duncan, Maderspach, et al., 1996; Maduna, Audouard, Dembélé, et al., 2019; Meyer, Paisley, Mohamed, et al., 2017; Mika, Popiolek-Barczyk, Rojewska, et al., 2014; Nam, Han, Lee, et al., 2018; Shrivastava, Cabrera, Chastain, et al., 2017; Woo, Bae, Nam, et al., 2018). However, whether or not these receptors mediate opioid-induced glial activation remains unclear.
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2020, Brain Research BulletinCitation Excerpt :However, only μ opioid receptors (MOR) were thought to associate with the rewarding effect of opioid drugs. Previous studies have shown that all these opioid receptors were found to be expressed by both microglia and astrocytes (Chao et al., 1996; Dobrenis et al., 1995; Eriksson et al., 1992; Fu et al., 2007; Gurwell et al., 1996; Maduna et al., 2018; Meyer et al., 2017; Mika et al., 2014; Nam et al., 2018; Shrivastava et al., 2017; Woo et al., 2018). Surprisingly, very few studies have explored if the activation of these opioid receptors may stimulate glial cell activities or not.
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2012, Experimental NeurologyCitation Excerpt :Importantly, proinflammatory central immune signaling events have been implicated in some of these behavioral consequences following opioid engagement of non-classical opioid systems. Nonetheless, immunocompetent cells within the CNS, including but not limited to, microglia (Bokhari et al., 2009; Chao et al., 1996, 1997; Horvath et al., 2010) and astrocytes (Bunn et al., 1985; Burbassi et al., 2010; Dobrenis et al., 1995; Festa et al., 2002; Hauser et al., 1996; Maderspach et al., 1995; Ruzicka et al., 1996; Thorlin et al., 1998) express opioid receptors. However, the role of the opioid receptor in initiating central immune signaling is unclear as it has been demonstrated that some TLRs (eg TLR2 and TLR4) are also capable of recognizing opioids.