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Nitric oxide neurons and neurotransmission
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2008, Pharmacology and TherapeuticsNitric oxide and penile erectile function
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2004, Journal of Sexual MedicineCitation Excerpt :Cholinergic nerves are present in the corpus cavernosum and seem to have a modulator role on the other neuroeffector systems. Acetylcholine inhibits neurogenic relaxation mediated by NO in dog cerebral arteries [102,103]. In contrast, physostigmine (an inhibitor of acetylcholinesterase that potentiates acetylcholine‐mediated effects) significantly potentiates neurogenic relaxation of human corpus cavernosum smooth muscle [52], suggesting the possibility that acetylcholine, via muscarinic receptors on nitrergic nerves, potentiates the release of NO in human penile tissue.
Neurogenic cerebral vasodilation mediated by nitric oxide
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