Vanilloid (capsaicin) receptors in the rat: distribution in the brain, regional differences in the spinal cord, axonal transport to the periphery, and depletion by systemic vanilloid treatment
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2018, Biophysical JournalModulation of neuroinflammation: Role and therapeutic potential of TRPV1 in the neuro-immune axis
2017, Brain, Behavior, and ImmunityCitation Excerpt :Many studies have suggested that TRPV1 expresses not merely in neurons, but also in glial cells in mammals, including humans (Ho et al., 2014; Miyake et al., 2015). However, the distribution of TRPV1 in glial cells remains debatable regarding the extent and localization, some initial seminal reports showed very low or no expression in the CNS (Caterina et al., 1997; Szallasi et al., 1995), while recently, the expression of TRPV1 in glial cells has been fully verified with the help of innovative approaches, including pharmacological characterization, immunohistochemistry, radio ligand binding, RT-PCR and in situ hybridization (Martins et al., 2014). Functional expression of TRPV1 was reported in rodent and human microglial cells, mainly located in the hippocampus, cortex, hypothalamus, cerebellum, substantia nigra, olfactory system, mesencephalon, and hindbrain in the brain (Hironaka et al., 2014; Huang et al., 2014, 2015; Sun et al., 2013; Toth et al., 2005) and also in the spinal cord, retina and visual cortex (Sappington and Calkins, 2008; Talbot et al., 2012).
Supraspinal TRPV1 modulates the emotional expression of abdominal pain
2014, PainCitation Excerpt :The capsaicin receptor has been found and studied not only in the peripheral nervous system but also in the brain. Although there are conflicting reports about cerebral TRPV1 localization and expression ranging from a lack of receptor expression, or very restricted to widespread receptor expression in the central nervous system (CNS) [10,35,45,51], the neurobehavioral relevance of the receptor has been thoroughly analyzed and confirmed in several rodent studies. For instance, it has been shown that TRPV1 contributes to anxiety, fear, and panic-like responses in brain regions related to defensive responses such of those of the hippocampus, the periaqueductal gray (PAG), or the medial prefrontal cortex [6,18,32].